For patients with septic shock and high circulating endotoxin levels, adding polymyxin B hemoperfusion treatment did not improve 28-day mortality rate.
For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.
Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.
Sepsis associated with treatment for acute lymphoblastic leukemia in pediatric patients can affect long-term neurocognitive function.
Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.
Patients recovering from sepsis had an elevated risk for myocardial infarction or stroke in the first 4 weeks after hospital discharge compared to the general population.
Prehospital advanced life support, but not basic life support only, care was associated with faster antibiotic initiation for patients with sepsis without hypotension.
Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.
For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed strategy.
The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.
Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis.
The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.
Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock
A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.
Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality RiskJuly 10, 2018
qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.
Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.
Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.
Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.
The percentage of patients with septic arthritis related to opioid or injection drug use was found to have increased from 2000 to 2013.
Risk of death from sepsis increased at hospitals with lowest volume of immunosuppressed patients with sepsis.
Systematic early lactate measurements speed antibiotic administration, improve outcomes.
Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.
Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.
The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.
The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.
In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.
Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.
Study demonstrated a new approach to incorporate time ("delay") when analyzing the effect on outcomes and provided new evidence for clinical practice and research of severe sepsis or septic shock.
Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.
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