Sepsis
Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock
December 04, 2018For patients with septic shock and high circulating endotoxin levels, adding polymyxin B hemoperfusion treatment did not improve 28-day mortality rate.
Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A
November 29, 2018For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.
Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine
November 08, 2018Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.
Sepsis Can Affect Long Term Neurocognitive Dysfunction in Children With ALL
November 05, 2018Sepsis associated with treatment for acute lymphoblastic leukemia in pediatric patients can affect long-term neurocognitive function.
Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis
October 29, 2018Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.
Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis
October 23, 2018Patients recovering from sepsis had an elevated risk for myocardial infarction or stroke in the first 4 weeks after hospital discharge compared to the general population.
Prehospital Care Lessens Antibiotic Delay in Patients With Sepsis
October 18, 2018Prehospital advanced life support, but not basic life support only, care was associated with faster antibiotic initiation for patients with sepsis without hypotension.
Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear
October 16, 2018Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.
Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis
October 15, 2018For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed strategy.
The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread
October 11, 2018The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.
Vitamin D Deficiency Associated With Sepsis Mortality
October 04, 2018Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.
Critics Demand Stop to Sepsis Clinical Trial
September 28, 2018Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis.
Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis
September 24, 2018The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.
New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality
August 16, 2018Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock
Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk
July 24, 2018A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.
Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk
July 10, 2018qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.
Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients
June 27, 2018Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.
Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis
June 19, 2018Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.
Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients
June 15, 2018Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.
IV Drug Use Associated With Increased Mortality in Septic Arthritis
June 15, 2018The percentage of patients with septic arthritis related to opioid or injection drug use was found to have increased from 2000 to 2013.
Case Volume Affects Sepsis Mortality in Immunosuppressed Patients
June 11, 2018Risk of death from sepsis increased at hospitals with lowest volume of immunosuppressed patients with sepsis.
Delay of Lactate Draws in Sepsis Ups Risk of In-Hospital Death
May 30, 2018Systematic early lactate measurements speed antibiotic administration, improve outcomes.
Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis
May 29, 2018Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.
Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis
May 25, 2018Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.
Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS
May 23, 2018The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.
Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS
May 15, 2018The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.
Infections Complicating the Use of Monoclonal Antibodies for Malignancy
May 07, 2018In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.
How Important Is the Timing of Antibiotics for Surviving Sepsis?
May 01, 2018Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.
Delayed Management of Severe Sepsis, Septic Shock Increases Mortality
April 25, 2018Study demonstrated a new approach to incorporate time ("delay") when analyzing the effect on outcomes and provided new evidence for clinical practice and research of severe sepsis or septic shock.
Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock
April 19, 2018Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.
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Infectious Disease Advisor Articles
- Novel H pylori Eradication Therapy Effective in Phase 3 Trial
- Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock
- New Four Drug Regimen Effective in Patients With HCV Who Inject Drugs
- Pediatric ART Leads to Increasing Mitochondrial DNA Mutations
- Prior Influenza Vaccination Not Associated With Future Vaccine Efficacy in Children
- Survival Similar With Donor Hearts From Donors With Hepatitis C
- No Adverse Pregnancy or Infant Outcomes With Dapivirine Use in Periconception
- Dundee Severity Classification Improves Management of Patients With Cellulitis
- Updated Recommendations, Hepatitis A Vaccine Postexposure Prophylaxis and Travel
- Klebsiella pneumoniae With PKS Gene Cluster Increases 30-Day Mortality
