Sepsis

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

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For patients with septic shock and high circulating endotoxin levels, adding polymyxin B hemoperfusion treatment did not improve 28-day mortality rate.

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

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For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

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Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.

Sepsis Can Affect Long Term Neurocognitive Dysfunction in Children With ALL

Sepsis Can Affect Long Term Neurocognitive Dysfunction in Children With ALL

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Sepsis associated with treatment for acute lymphoblastic leukemia in pediatric patients can affect long-term neurocognitive function.

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

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Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.

Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis

Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis

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Patients recovering from sepsis had an elevated risk for myocardial infarction or stroke in the first 4 weeks after hospital discharge compared to the general population.

Prehospital Care Lessens Antibiotic Delay in Patients With Sepsis

Prehospital Care Lessens Antibiotic Delay in Patients With Sepsis

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Prehospital advanced life support, but not basic life support only, care was associated with faster antibiotic initiation for patients with sepsis without hypotension.

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

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Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis

For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed strategy.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

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The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Vitamin D Deficiency Associated With Sepsis Mortality

Vitamin D Deficiency Associated With Sepsis Mortality

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Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.

Critics Demand Stop to Sepsis Clinical Trial

Critics Demand Stop to Sepsis Clinical Trial

Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis.

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

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The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

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Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

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A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

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qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

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Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

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Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

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Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.

IV Drug Use Associated With Increased Mortality in Septic Arthritis

IV Drug Use Associated With Increased Mortality in Septic Arthritis

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The percentage of patients with septic arthritis related to opioid or injection drug use was found to have increased from 2000 to 2013.

 Case Volume Affects Sepsis Mortality in Immunosuppressed Patients

Case Volume Affects Sepsis Mortality in Immunosuppressed Patients

Risk of death from sepsis increased at hospitals with lowest volume of immunosuppressed patients with sepsis.

Delay of Lactate Draws in Sepsis Ups Risk of In-Hospital Death

Delay of Lactate Draws in Sepsis Ups Risk of In-Hospital Death

Systematic early lactate measurements speed antibiotic administration, improve outcomes.

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

Procalcitonin Is Effective Biomarker for Guiding Antibiotic Treatment in Sepsis

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Researchers conducted a literature review to assess the effectiveness and safety of procalcitonin to guide treatment in patients with known or suspected sepsis.

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

Early Flow Cytometry Predictive of Clinical Deterioration in Sepsis

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Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

Molecular Laboratory Test Can Discriminate Sepsis From Noninfectious SIRS

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The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

Best Diagnosis for Sepsis May Be a 2-Step Approach With qSOFA and SIRS

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The association of both criteria (qSOFA and SIRS) could provide a better model to initiate or escalate therapy in patients with sepsis.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

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In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

How Important Is the Timing of Antibiotics for Surviving Sepsis?

How Important Is the Timing of Antibiotics for Surviving Sepsis?

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Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

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Study demonstrated a new approach to incorporate time ("delay") when analyzing the effect on outcomes and provided new evidence for clinical practice and research of severe sepsis or septic shock.

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

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Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.

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