Sepsis

Pneumococcal Sepsis Risk Remains High in Children After Vaccination

Pneumococcal Sepsis Risk Remains High in Children After Vaccination

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The incidence of pneumococcal sepsis in children remained substantial after the introduction of the pneumococcal conjugate vaccine in Switzerland.

No Association Between LDL Cholesterol Levels and Risk for Sepsis

No Association Between LDL Cholesterol Levels and Risk for Sepsis

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A low level of LDL cholesterol was initially associated with increased risk for sepsis and admission to the ICU.

Practices Vary in Treating Adult <i>Staphylococcus aureus</i> Bacteremia

Practices Vary in Treating Adult Staphylococcus aureus Bacteremia

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Practices vary among clinicians in diagnosing and managing Staphylococcus aureus bacteremia in adults.

Use of Single-Family Rooms Reduces Incidence of Neonatal Sepsis

Use of Single-Family Rooms Reduces Incidence of Neonatal Sepsis

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Using a single-family room setting significantly reduced neonatal sepsis and improved breastfeeding rates at discharge.

Corticosteroid Use Reduces 28-Day Mortality in Sepsis

Corticosteroid Use Reduces 28-Day Mortality in Sepsis

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The administration of corticosteroids in patients with sepsis may be associated with significant improvement in patient outcomes.

Scenario-Based Survey of Empiric Antibiotic Treatment Thresholds

Scenario-Based Survey of Empiric Antibiotic Treatment Thresholds

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80 to 90% pathogen coverage was acceptable to physicians as a threshold for managing patients with mild and severe sepsis from bacterial infections.

Worse Outcomes in Community-Acquired Pneumonia Linked to Higher FGF21 Levels

Worse Outcomes in Community-Acquired Pneumonia Linked to Higher FGF21 Levels

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Patients diagnosed with community-acquired pneumonia with higher levels of fibroblast growth factor-21 may have higher mortality rates and longer hospitalizations.

Risk Factors for Repeat Surgery Identified in Septic Arthritis of the Hip

Risk Factors for Repeat Surgery Identified in Septic Arthritis of the Hip

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Investigators identified risk factors for repeat surgical intervention after initial arthrotomy for presumed septic arthritis of the hip.

Early IV Fluids Linked to Lower Mortality in Some Patients With Sepsis

Early IV Fluids Linked to Lower Mortality in Some Patients With Sepsis

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Early administration of IV fluids by paramedics to patients with sepsis was linked with lower mortality, but only in patients with low initial systolic BP.

Emergency Department Overcrowding Associated With Delayed Antibiotics in Patients With Sepsis

Emergency Department Overcrowding Associated With Delayed Antibiotics in Patients With Sepsis

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Crowding in the emergency department was associated with the timely administration of antibiotics for patients presenting with sepsis.

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock

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For patients with septic shock and high circulating endotoxin levels, adding polymyxin B hemoperfusion treatment did not improve 28-day mortality rate.

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

Re-Assessing Renal Dose Adjustments of Antibiotics: Expert Q&A

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For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

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Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.

Sepsis Can Affect Long Term Neurocognitive Dysfunction in Children With ALL

Sepsis Can Affect Long Term Neurocognitive Dysfunction in Children With ALL

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Sepsis associated with treatment for acute lymphoblastic leukemia in pediatric patients can affect long-term neurocognitive function.

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

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Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.

Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis

Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis

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Patients recovering from sepsis had an elevated risk for myocardial infarction or stroke in the first 4 weeks after hospital discharge compared to the general population.

Prehospital Care Lessens Antibiotic Delay in Patients With Sepsis

Prehospital Care Lessens Antibiotic Delay in Patients With Sepsis

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Prehospital advanced life support, but not basic life support only, care was associated with faster antibiotic initiation for patients with sepsis without hypotension.

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

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Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis

For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed strategy.

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

The Misuse of Antibiotics in Acute Pancreatitis Appears Widespread

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The inappropriate use of antibiotics as prophylaxis and treatment in acute pancreatitis is common, highlighting the efforts required for antibiotic stewardship.

Vitamin D Deficiency Associated With Sepsis Mortality

Vitamin D Deficiency Associated With Sepsis Mortality

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Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.

Critics Demand Stop to Sepsis Clinical Trial

Critics Demand Stop to Sepsis Clinical Trial

Clovers trial seeks to determine which IV fluids, vasopressors combo works best to curb sepsis.

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

Corticosteroid Use May Modestly Reduce Mortality Risk in Sepsis

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The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

New York State Mandate for Pediatric Sepsis Bundled Care Linked to Lower Mortality

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Completion of a care bundle for pediatric patients within 1 hour of sepsis recognition, which includes blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus, was associated with lower in-hospital mortality among children with sepsis and septic shock

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

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A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

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qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

Prognostic Biomarkers to Guide Antibiotic Therapy in Critically Ill Patients

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Proadrenomedullin and procalcitonin have demonstrated superiority to C-reactive protein for predicting mortality and guiding antimicrobial therapy in critically ill patients with fever.

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

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Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

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Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.

IV Drug Use Associated With Increased Mortality in Septic Arthritis

IV Drug Use Associated With Increased Mortality in Septic Arthritis

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The percentage of patients with septic arthritis related to opioid or injection drug use was found to have increased from 2000 to 2013.

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