Septic Shock

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

Presenting With Vague Symptoms May Increase Septic Shock Mortality Risk

By

A large proportion of patients with septic shock but who present to the ED with vague symptoms not specific to infection have a significantly higher mortality rate than those with symptoms that are explicit to an infection.

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

Delays in Lactate Testing Associated With Delayed Antibiotics, Increased Mortality in Sepsis

By

Delayed lactate measurement is associated with delayed antibiotic administration and increased mortality in patients with increased lactate levels.

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

Sepsis-3 Septic Shock Criteria vs SIRS to Predict Mortality in Hospitalized Patients

By

Although the Systemic Inflammatory Response Syndrome criteria have been used for decades to identify sepsis in patients with suspected infection, they have been re-evaluated in the Third International Consensus Definitions for Sepsis and Septic Shock.

How Important Is the Timing of Antibiotics for Surviving Sepsis?

How Important Is the Timing of Antibiotics for Surviving Sepsis?

By

Early antibiotic administration in treating infection has evident biological plausibility, however, time-sensitivity to outcomes appears to be most relevant in septic shock.

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

Delayed Management of Severe Sepsis, Septic Shock Increases Mortality

By

Study demonstrated a new approach to incorporate time ("delay") when analyzing the effect on outcomes and provided new evidence for clinical practice and research of severe sepsis or septic shock.

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

Arterial Lactate Level a Reliable Prognostic Predictor for Septic Shock

By

Researchers evaluated the prognostic significance of the cutoff value for lactate via comparison of clinical presentation and outcome between patients with septic shock with high and low lactate levels.

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

By

In patients with insulin-treated diabetes and sepsis, increased highest glucose levels and glycemic variability have a significant illness severity-adjusted association with decreasing in-hospital mortality.

Hydrocortisone Plus Fludrocortisone Lowers Mortality in Septic Shock

Hydrocortisone Plus Fludrocortisone Lowers Mortality in Septic Shock

By

In this study involving patients with septic shock, 90-day all-cause mortality was lower in patients who received hydrocortisone plus fludrocortisone than in patients who received placebo.

Hydrocortisone plus fludrocortisone decreases mortality in adults with septic shock

Patients with septic shock in the intensive care unit undergoing mechanical ventilation receiving hydrocortisone plus fludrocortisone had a lower 90-day all-cause mortality compared to placebo treated patients.

Adjunctive glucocorticoid therapy does not lower mortality in septic shock

Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion, did not have a lower 90-day mortality compared to placebo.

No Benefit of Induced Hypothermia for Septic Shock

No Benefit of Induced Hypothermia for Septic Shock

By

Induced hypothermia (target temperature 32°C-34°C) proved harmful with regards to respiratory function and it also prolonged septic shock.

Effectiveness of Hydrocortisone Infusion in Septic Shock

Effectiveness of Hydrocortisone Infusion in Septic Shock

By

Adjunctive glucocorticoid therapy in patients with septic shock may reduce the duration of shock.

IDSA and SCCM Sepsis Guidelines Controversy: An Expert Perspective

IDSA and SCCM Sepsis Guidelines Controversy: An Expert Perspective

By

Stanford T. Shulman, MD, editorial advisory board member for Infectious Disease Advisor, outlines reasons why IDSA elected not to endorse the 2016 Surviving Sepsis Campaign Guidelines.

Reduced Incidence of Sepsis in Patients With Asthma

Reduced Incidence of Sepsis in Patients With Asthma

Asthma patients with infections have a reduced risk of developing sepsis.

Case of <i>Vibrio vulnificus</i> Septic Shock Leading to Death After New Tattoo

Case of Vibrio vulnificus Septic Shock Leading to Death After New Tattoo

By

A patient who recently acquired a new tattoo developed Vibrio vulnificus septic shock after swimming in seawater, leading to death.

Does Early Goal-Directed Therapy Reduce Mortality in Septic Shock?

Does Early Goal-Directed Therapy Reduce Mortality in Septic Shock?

By

Three multicenter trials (ProCESS, ARISE, and ProMISe) showed that EGDT did not reduce mortality in patients presenting to the emergency department with septic shock when compared to usual care.

Shortage of Norepinephrine Linked to Increase in Septic Shock Deaths

Shortage of Norepinephrine Linked to Increase in Septic Shock Deaths

By

Hospitals see higher rate of in-hospital mortality from septic shock after norepinephrine shortage.

Hydrocortisone Does Not Reduce Risk of Septic Shock in Severe Sepsis

Hydrocortisone Does Not Reduce Risk of Septic Shock in Severe Sepsis

By

Researchers did not observe a significant improvement with hydrocortisone over placebo for time until septic shock or mortality.

Sign Up for Free e-newsletters