Investigators examined tolerability, effectiveness, and safety profile of topical antibacterial agent ozenoxacin in adults and children with impetigo.
Six-week antibiotic treatment is sufficient for early, spinal surgery site infections.
Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.
The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.
A 9-point risk assessment (IVAT) identified persons with a history of injection drug use (IDU) safe for discharge and reduced the mean length of hospital stay (ALOS) by 20 days and total direct cost by 33%.
The structure of contezolid was designed to potentially reduce the risk of hematological toxicity associated with this class of antibiotics.
The widespread implementation of ALT-70 into clinical practice may help decrease misdiagnosis rates of lower-extremity cellulitis.
The journal Annals of Emergency Medicine recently published an article reviewing the tools used to diagnose necrotizing soft tissue infection.
After cesarean delivery, the incision site harbors a higher bacterial biomass in obese women than in non-obese women.
The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.
Staphylococcal scalded skin syndrome is associated with substantial patient morbidity and costs.
The NDA includes safety and efficacy data from two Phase 3 trials (REVIVE-1 and REVIVE-2; N=1190) which compared intravenous iclaprim to standard-of-care vancomycin in patients with ABSSSI.
Researchers assessed the incidence of Cutibacterium avidum infection in patients following primary hip arthroplasty.
Deployment-related trauma infectious complications continue after initial hospital discharge and into Veterans Affairs healthcare.
The morphology of the lesions included erythematous papules, pseudovesicles, and plaques, with associated pain in 2 and pruritus in 3 patients; systemic symptoms ranged from none to low‐grade fevers, upper respiratory symptoms, and joint pain.
Omadacycline met all required FDA and European Medicines Agency primary endpoints in each study and demonstrated a generally safe and well-tolerated profile.
Researchers reviewed clinical trial data to evaluate the efficacy of herpes zoster subunit vaccine in preventing complications, hospitalizations, and deaths.
GBS infections in infants, cellulitis and necrotizing fasciitis, although uncommon in infants, requires swift treatment with antibiotics and occasionally surgical debridement.
Trimethoprim and sulfamethoxazole or clindamycin confer a modest benefit for several important outcomes, but this is offset by a similar risk for adverse effects.
Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.
Strains of Staphylococcus epidermidis producing 6-N-hydroxyaminopurine (6-HAP) may provide protection against skin cancer.
Organ systems where bacterial infections predominate as well as fungal diseases were associated with substantial increases in magnitude among patients with both T1D and T2D, but risks were consistently higher for T1D.
The Advisory Committee on Immunization Practices has provided 3 new recommendations to supplement its original 2008 report, as well as a cost-effectiveness analysis from the CDC.
Melinta Therapeutics announced the availability of oral and intravenous forms of Baxdela (delafloxacin) for the treatment of adults with ABSSSI.
A case of remission of psoriasis after treatment of chronic hepatitis C virus has been described.
Iclaprim was noninferior to vancomycin with respect to the early clinical response at an early time point in the treatment of ABSSSI caused or suspected to be caused by gram-positive organisms.
Long-term oral macrolide administration may increase macrolide-resistant Propionibacterium acnes.
Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.
Risk of herpes zoster (HZ) is not significantly increased for systemically treated patients or for those receiving biologics vs nonbiologics in psoriasis.
Atopic dermatitis disease severity is associated with IgG responses against Staphylococcus aureus antigens.
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Infectious Disease Advisor Articles
- Topical Antibacterial Agent Effective for Treatment of Impetigo
- Novel H pylori Eradication Therapy Effective in Phase 3 Trial
- Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock
- Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders
- Guideline Adoption for Childhood Community-Acquired Pneumonia
- High Sensitivity, Specificity for Chlamydia Point-of-Care Test
- Infections Linked to Increased Later Risk for Mental Disorders
- Glecaprevir/Pibrentasvir Effective in Hepatitis C Genotypes 5 and 6
- Invasive Pneumococcal Disease Risk Higher in Premature Infants
- Management Mycobacterium chimaera Outbreak From Heater-Cooler Units