Skin Infections

Topical Antibacterial Agent Effective for Treatment of Impetigo

Topical Antibacterial Agent Effective for Treatment of Impetigo

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Investigators examined tolerability, effectiveness, and safety profile of topical antibacterial agent ozenoxacin in adults and children with impetigo.

6-Week Antibiotic Treatment Effective for Spinal Surgery Site Infections

6-Week Antibiotic Treatment Effective for Spinal Surgery Site Infections

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Six-week antibiotic treatment is sufficient for early, spinal surgery site infections.

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

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Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Omadacycline Approved for  Community-Acquired Bacterial Pneumonia, Skin Infections

Omadacycline Approved for Community-Acquired Bacterial Pneumonia, Skin Infections

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The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.

Risk Assessment Reduces Length of Hospital Stay, Costs in Patients who Inject Drugs

Risk Assessment Reduces Length of Hospital Stay, Costs in Patients who Inject Drugs

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A 9-point risk assessment (IVAT) identified persons with a history of injection drug use (IDU) safe for discharge and reduced the mean length of hospital stay (ALOS) by 20 days and total direct cost by 33%.

FDA Gives MRX-I QIDP, Fast Track Status for Acute Bacterial Skin Infections

FDA Gives MRX-I QIDP, Fast Track Status for Acute Bacterial Skin Infections

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The structure of contezolid was designed to potentially reduce the risk of hematological toxicity associated with this class of antibiotics.

 ALT-70 Model Provides Accurate Diagnosis of Lower Extremity Cellulitis

ALT-70 Model Provides Accurate Diagnosis of Lower Extremity Cellulitis

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The widespread implementation of ALT-70 into clinical practice may help decrease misdiagnosis rates of lower-extremity cellulitis.

Review of Diagnostic Tools for Necrotizing Soft Tissue Infections

Review of Diagnostic Tools for Necrotizing Soft Tissue Infections

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The journal Annals of Emergency Medicine recently published an article reviewing the tools used to diagnose necrotizing soft tissue infection.

Skin Microbiota Differ for Obese, Non-Obese Undergoing C-Section

Skin Microbiota Differ for Obese, Non-Obese Undergoing C-Section

After cesarean delivery, the incision site harbors a higher bacterial biomass in obese women than in non-obese women.

FDA Approves Omadacycline for Skin Infections, Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Increasing Incidence of Staphylococcal Scalded Skin Syndrome in the United States

Increasing Incidence of Staphylococcal Scalded Skin Syndrome in the United States

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Staphylococcal scalded skin syndrome is associated with substantial patient morbidity and costs.

NDA Submitted for Novel, Targeted Antibiotic Iclaprim

NDA Submitted for Novel, Targeted Antibiotic Iclaprim

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The NDA includes safety and efficacy data from two Phase 3 trials (REVIVE-1 and REVIVE-2; N=1190) which compared intravenous iclaprim to standard-of-care vancomycin in patients with ABSSSI.

Higher Groin <I>C Avidum</I> Colonization in Obese Patients After Hip Arthroplasty

Higher Groin C Avidum Colonization in Obese Patients After Hip Arthroplasty

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Researchers assessed the incidence of Cutibacterium avidum infection in patients following primary hip arthroplasty.

Military Personnel Remain at Risk for Infection Long After Hospital Discharge

Military Personnel Remain at Risk for Infection Long After Hospital Discharge

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Deployment-related trauma infectious complications continue after initial hospital discharge and into Veterans Affairs healthcare.

Herpes Zoster in Healthy Children Linked to Varicella-Zoster Vaccination

Herpes Zoster in Healthy Children Linked to Varicella-Zoster Vaccination

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The morphology of the lesions included erythematous papules, pseudovesicles, and plaques, with associated pain in 2 and pruritus in 3 patients; systemic symptoms ranged from none to low‐grade fevers, upper respiratory symptoms, and joint pain.

Omadacycline Granted Priority Review for CABP, Skin/Skin Structure Infections

Omadacycline Granted Priority Review for CABP, Skin/Skin Structure Infections

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Omadacycline met all required FDA and European Medicines Agency primary endpoints in each study and demonstrated a generally safe and well-tolerated profile.

Vaccine Lessens Incidence of Herpes Zoster Complications in Immuncompetent Older Adults

Vaccine Lessens Incidence of Herpes Zoster Complications in Immuncompetent Older Adults

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Researchers reviewed clinical trial data to evaluate the efficacy of herpes zoster subunit vaccine in preventing complications, hospitalizations, and deaths.

When to Suspect GBS Cellulitis and Necrotizing Fasciitis in Infants

When to Suspect GBS Cellulitis and Necrotizing Fasciitis in Infants

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GBS infections in infants, cellulitis and necrotizing fasciitis, although uncommon in infants, requires swift treatment with antibiotics and occasionally surgical debridement.

Adjunctive Antibiotic Therapy Yields Modest Benefit in Uncomplicated Skin Abscesses

Adjunctive Antibiotic Therapy Yields Modest Benefit in Uncomplicated Skin Abscesses

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Trimethoprim and sulfamethoxazole or clindamycin confer a modest benefit for several important outcomes, but this is offset by a similar risk for adverse effects.

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

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Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.

Strains of <i>S epidermidis</i> May Help Protect Against Skin Cancer

Strains of S epidermidis May Help Protect Against Skin Cancer

Strains of Staphylococcus epidermidis producing 6-N-hydroxyaminopurine (6-HAP) may provide protection against skin cancer.

Increased Risk of Serious Infections With Type 1 Diabetes

Increased Risk of Serious Infections With Type 1 Diabetes

Organ systems where bacterial infections predominate as well as fungal diseases were associated with substantial increases in magnitude among patients with both T1D and T2D, but risks were consistently higher for T1D.

ACIP: New Recommendations for Herpes Zoster Vaccine Administration

ACIP: New Recommendations for Herpes Zoster Vaccine Administration

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The Advisory Committee on Immunization Practices has provided 3 new recommendations to supplement its original 2008 report, as well as a cost-effectiveness analysis from the CDC.

Oral, Intravenous Delafloxacin Now Available for ABSSSI Treatment

Oral, Intravenous Delafloxacin Now Available for ABSSSI Treatment

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Melinta Therapeutics announced the availability of oral and intravenous forms of Baxdela (delafloxacin) for the treatment of adults with ABSSSI.

Case of Psoriasis Remission After Hepatitis C Treatment

Case of Psoriasis Remission After Hepatitis C Treatment

A case of remission of psoriasis after treatment of chronic hepatitis C virus has been described.

Iclaprim Comparable With Vancomycin for Gram-Positive Acute Bacterial Skin Infections

Iclaprim Comparable With Vancomycin for Gram-Positive Acute Bacterial Skin Infections

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Iclaprim was noninferior to vancomycin with respect to the early clinical response at an early time point in the treatment of ABSSSI caused or suspected to be caused by gram-positive organisms.

Long-Term Macrolide Use Increases Risk of Resistant <i>P acnes</i>

Long-Term Macrolide Use Increases Risk of Resistant P acnes

Long-term oral macrolide administration may increase macrolide-resistant Propionibacterium acnes.

Safety of Clofazimine in Treating Children With <i>Mycobacterium abscessus</i> Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

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Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

No Difference in Herpes Zoster Risk With Biologic- vs Nonbiologic-Treated Psoriasis

No Difference in Herpes Zoster Risk With Biologic- vs Nonbiologic-Treated Psoriasis

Risk of herpes zoster (HZ) is not significantly increased for systemically treated patients or for those receiving biologics vs nonbiologics in psoriasis.

IgG Response to <i>S aureus</i> Linked to Severe Atopic Dermatitis in Children

IgG Response to S aureus Linked to Severe Atopic Dermatitis in Children

Atopic dermatitis disease severity is associated with IgG responses against Staphylococcus aureus antigens.

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