Early Bactericidal Activity of High-Dose Isoniazid for Drug Resistant TB
Daily doses of 10 to 15 mg/kg isoniazid demonstrated similar activity against tuberculosis (TB) strains with inhA mutations as 5 mg/kg doses against drug-sensitive strains.
Antibiotic Stewardship
Dual Therapy With Vonoprazan, Amoxicillin Effective For Helicobacter pylori
Dual therapy with vonoprazan and low-dose amoxicillin had similar efficacy to triple-drug treatment for the eradication of Helicobacter pylori.
QOL Similar After Surgery, Antibiotics for Uncomplicated Appendicitis
For patients being treated for uncomplicated acute appendicitis, quality of life (QOL) is similar at seven years after appendectomy or antibiotic therapy.
How Effective Is the WHO Recommended Antibiotic Regimen for Leprosy?
The multidrug antibiotic regimen for the treatment of paucibacillary and multibacillary leprosy seemed to show better clinical improvement of lesions compared with rifampin, ofloxacin, and minocycline and other treatment.
Latent TB Infection Treatment: 4 Months of Rifampin vs 9 Months of Isoniazid
Treatment with 4 months of rifampin for latent tuberculosis infection was associated with higher adherence, lower costs, and lower risk for severe hepatoxicity compared with 9 months of isoniazid.
Many Antibiotic Prescriptions Filled Without Infection-Related Diagnosis
More than one-quarter of antibiotic fills for Medicaid patients not associated with a clinician visit
Long-Duration Vancomycin May Reduce Recurrence of Clostridioides difficile
The study researchers concluded that when compared with short-duration vancomycin therapy for the treatment of CDI, long-duration vancomycin therapy was associated with significantly lower CDI recurrence rates.
Allergic Reactions to Non-Beta-Lactam Antibiotics
A study on pediatric antibiotic sensitivities and allergies provided information particularly relevant to pediatric, family practice, and infectious disease practices.
Biomarker-Guided Exclusion of VAP Does Not Reduce Antibiotic Use
Biomarker-guided exclusion of ventilator-associated pneumonia was not associated with a reduction in antibiotic use.
Reliance on Historic Breakpoints May Lead to False Antimicrobial Susceptibility Reports
Failure to adopt updated antimicrobial susceptibility testing breakpoints may lead to reports of false susceptibility for antimicrobials commonly used to treat Gram-negative infections and preclude recognition of CRE.
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