Linezolid-Containing Regimen as Empiric Treatment for Moderate to Severe Nocardiosis
Linezolid use in combination therapy is effective and as safe as other firstline treatments for moderate to severe nocardiosis.
Antibiotic Stewardship
Pharmacokinetic Analysis of an Extended-Pulsed Fidaxomicin Regimen
Extended-pulsed fidaxomicin regimen for treatment of C difficile infection maintained fidaxomicin stool concentrations above the minimum inhibitory concentration required to inhibit the growth of 90% of organisms for 26 days.
Multiple-Dose Fosfomycin for Complicated UTIs
In cases of complicated urinary tract infections (UTI) treated with multiple-dose fosfomycin, clinical resolution occurred in 2 of 3 treatment episodes.
Updated Guidelines for Latent TB Infection Treatment Released by CDC and NTCA
The National Tuberculosis Controllers Association and the Centers for Disease Control and Prevention have released updated guidelines for the treatment of latent tuberculosis infection.
C difficile Risk and Antibiotic Prescription Choices
Large variations in Clostridioides difficile infection risk resulting from antibiotic courses used for the same indications were identified.
Vancomycin for Acute Bacterial Skin and Skin Structure Infection
Using oral antibiotics when possible and limiting the durations of vancomycin treatment may decrease vancomycin-associated acute kidney injury in patients with acute bacterial skin and skin structure infections.
Pneumonia Mortality Not Improved With Empiric Anti-MRSA Therapy
Anti-methicillin-resistant Staphylococcus aureus (MRSA) therapy in addition to standard pneumonia therapy does not improve mortality.
Piperacillin-Tazobactam May Not Be Comparable to Carbapenem
In this letter to the editor, the authors raise a serious concern about the selection bias in the study by Sharara, et al with the results published in Clinical Infectious Diseases.
Antibiotics, Corticosteroids Beneficial in COPD Exacerbations
For adults with exacerbation of chronic obstructive pulmonary disease, antibiotics and systemic corticosteroids are associated with less treatment failure.
Early Bactericidal Activity of High-Dose Isoniazid for Drug Resistant TB
Daily doses of 10 to 15 mg/kg isoniazid demonstrated similar activity against tuberculosis (TB) strains with inhA mutations as 5 mg/kg doses against drug-sensitive strains.
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