Multiple-Dose Fosfomycin for Complicated UTIs
In cases of complicated urinary tract infections (UTI) treated with multiple-dose fosfomycin, clinical resolution occurred in 2 of 3 treatment episodes.
Antibiotics
Pneumonia Mortality Not Improved With Empiric Anti-MRSA Therapy
Anti-methicillin-resistant Staphylococcus aureus (MRSA) therapy in addition to standard pneumonia therapy does not improve mortality.
Normal Dose Moxifloxacin Maintained Effectiveness in Rifampin-Resistant TB
A short, 9-month regimen of normal dose moxifloxacin maintained good effectiveness up to 24 months after therapy cessation in patients with rifampicin-resistant tuberculosis.
First Generic of Daraprim Gets FDA Approval
Pregnant women and patients with weakened immune systems (eg, HIV or AIDS) are most susceptible to severe complications from the infection.
Repeated Courses of Antibiotics Linked to Hospital Admissions
Repeated courses of antibiotics may be associated with adverse outcomes, including admissions for infection-related complications.
Piperacillin-Tazobactam May Not Be Comparable to Carbapenem
In this letter to the editor, the authors raise a serious concern about the selection bias in the study by Sharara, et al with the results published in Clinical Infectious Diseases.
Exebacase Gains Breakthrough Therapy Status for MRSA Bacteremia, Including Right-Sided Endocarditis
Exebacase is a novel, recombinantly-produced lysin (cell wall hydrolase enzyme), that targets the peptidoglycan cell wall.
Investigational Antibiotic Gets Orphan Drug Status for Pulmonary Exacerbations of Cystic Fibrosis
The FDA has granted Orphan Drug designation to ARV-1801 (sodium fusidate; Arrevus) for the treatment of pulmonary exacerbations in patients with cystic fibrosis.
Novel Cephalosporin Now Available for Treatment of Complicated UTI
Fetroja® (cefiderocol) has been made available by Shionogi for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex.
Antibiotics, Corticosteroids Beneficial in COPD Exacerbations
For adults with exacerbation of chronic obstructive pulmonary disease, antibiotics and systemic corticosteroids are associated with less treatment failure.
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