Mutation That Helps Coronavirus Evade Vaccines Showing Up in British Variant
Worrisome mutation known as E484K appears to have arisen coronavirus variant samples in the United Kingdom.
COVID19 Vaccine
COVID-19 Vaccine Efficacy After First Dose: Pfizer, Moderna, AstraZeneca
New data about Pfizer COVID-19 efficacy after the first dose suggests high efficacy, raising questions about potential alternative dosing schedules.
Pfizer-BioNTech: COVID-19 Vaccine Trial in Pregnant Women Begins; New Storage Data Submitted to FDA
The randomized, placebo-controlled, observer-blind study is evaluating the safety, tolerability, and immunogenicity of BNT162b2 in approximately 4000 healthy pregnant women aged 18 years and older who are 24 to 34 weeks’ gestation.
JAK-inhibitor and Type I Interferon Possible Treatments for COVID-19
Study authors conducted a systematic review and meta-analysis to assess the efficacy of Janus kinase-inhibitors and Type I interferons as potential antiviral candidates for the treatment of COVID-19.
Oxford-AstraZeneca COVID-19 Vaccine: New Study Results, Variant Coverage Update, Where Do We Stand?
The Oxford-AstraZeneca COVID-19 vaccine, ChAdOx1, released 4 studies to analyze its efficacy in the prevention of mild, moderate, and severe COVID-19 infection; new studies also address rising concerns in the vaccine’s ability to protect against variants B.1.1.7 and B.1.351.
ENSEMBLE Trial: J&J COVID-19 Vaccine Phase 3 Interim Analysis
Johnson & Johnson released interim analysis of its phase 3 EMSEMBLE trial for Ad.26.COV2, and provided more insight on overall protection in various countries, variant protection, and clinical outcomes.
EU Regulator Approves Oxford-AstraZeneca COVID-19 Vaccine
The Oxford-AstraZeneca COVID-19 vaccine is added to those made by Pfizer and Moderna, which have already been approved in the EU.
Merck Ends Development of Two COVID-19 Vaccine Candidates
While both candidates were found to be generally well tolerated, findings showed immune responses that were inferior to those seen after natural infection or those reported with other COVID-19 vaccines.
Moderna Wants to Increase Number of Doses in COVID-19 Vaccine Vials
The FDA is expected to make a decision on whether to allow Moderna to increase the number of doses in its vials of COVID-19 vaccine.
But Is it Fair? Bioethics, COVID-19 Vaccine Distribution, and Advocacy
We speak with Mildred Solomon, EdD, President of the Hastings Center and Professor of Global Health and Social Medicine at Harvard Medical School, where she directs the school’s Fellowship in Bioethics, about the COVID-19 pandemic, health equity, and vaccine distribution.
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