Exebacase Gains Breakthrough Therapy Status for MRSA Bacteremia, Including Right-Sided Endocarditis
Exebacase is a novel, recombinantly-produced lysin (cell wall hydrolase enzyme), that targets the peptidoglycan cell wall.
Sepsis
New Guidelines Issued for Cases of Pediatric Sepsis
For many PICO questions, the literature review failed to identify sufficient data to develop strong recommendations for children with septic shock or other sepsis-associated organ dysfunction.
Intestinal Microbiota Composition and Bloodstream Infection in Stem Cell Transplant Recipients
Among recipients of allogeneic hematopoietic cell transplantation (allo-HCT), gram-negative intestinal colonization is highly predictive of bloodstream infections.
Vitamin C, Hydrocortisone, Thiamine Not Superior to Hydrocortisone Alone for Septic Shock
For patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine did not significantly improve the duration of survival and free of vasopressor administration over 7 days.
Sepsis Incidence Underestimated, Remains Major Health Burden Worldwide
Results of a study are the first to produce global estimates of sepsis incidence and mortality across 195 countries and territories, 282 underlying causes of death, both sexes, and 23 age groups for the years 1990 to 2017.
Sepsis-Associated Mortality Rates Have Improved in Patients With Cancer
From 2003 to 2014, sepsis-associated mortality rates significantly declined in patients with cancer, yet these rates have remained relatively unchanged in patients without cancer.
Digital Sepsis Monitoring May Improve Inpatient Outcomes
A digital sepsis alert presents opportunity to improve care for patients who may have sepsis.
Incidence of Bloodstream Infections Lower in Recurrent CDI With Fecal Transplant
Patients with recurrent Clostridioides difficile infection (CDI) were less likely to develop bloodstream infections (BSI) if treated with fecal microbiota transplantation (FMT) compared with antibiotics.
Is Receiving Early Fluid Resuscitation Safe in Sepsis With Comorbidities?
Early fluid resuscitative efforts are important in patients with sepsis with cirrhosis, congestive heart failure, or end-stage renal disease to prevent acute respiratory failure.
No Link Found Between Per-Hour Delay in Antibiotics and Mortality in Septic Shock
In this study, we found that early first antibiotic administration was associated with improved outcomes in ED patients with septic shock using propensity score analysis.
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