Tebipenem HBr Gets Priority Review for Oral Treatment of Complicated UTI
The application includes data from the phase 3 ADAPT-PO trial, which evaluated the efficacy and safety of tebipenem HBr in 868 adults with cUTI or acute pyelonephritis.
Urinary Tract Infection
Safety, Efficacy of Aminoglycosides or Polymyxin Monotherapy for Complicated UTI
Researchers conducted a study to assess the safety and efficacy of aminoglycosides or polymyxin monotherapy for the treatment of adults with complicated urinary tract infections caused by extensively drug-resistant Pseudomonas aeruginosa.
Educating Nursing Care Facility Staff Decreases Inappropriate Antibiotic Treatment for Urinary Tract Infection
Researchers sought to determine whether an intervention to improve the knowledge and communication skills of nursing care facility staff decreases the number of inappropriate antibiotic prescriptions for patients with suspected urinary tract infection.
Probability of Progression to Complicated Urinary Tract Infection in Women With Antimicrobial-Resistant Isolates
Study finds that among women with uncomplicated urinary tract infection (UTI), those with antimicrobial-resistant isolates are at increased risk for progression to complicated UTI vs those with susceptible isolates.
Effect of Probenecid on Cephalexin Pharmacokinetics and Pharmacodynamics
Researchers conducted a crossover study to determine whether probenecid and cephalexin administered together increases the clinical benefits of cephalexin.
Community-Acquired Urinary Tract Infection: Adverse Effects of Cotrimoxazole vs Fluoroquinolones
Investigators conducted a cohort study that compared adverse effects and outcomes among patients with community-acquired urinary tract infection treated with cotrimoxazole vs fluoroquinolones.
Frailty Ups Risk for Urinary Tract Infections in Patients With Diabetes, CKD
More severe frailty predicted a higher risk of UTIs.
Study Supports Shorter Antibiotic Course for Afebrile Men With UTI
The double-blinded, placebo-controlled noninferiority study included a total of 272 afebrile men from 2 US Veterans Affairs medical centers.
FDA Needs More Data on Sulopenem for Uncomplicated UTI
The NDA submission was supported by data from the phase 3 SURE1 clinical trial.
UTI Study Maps Escherichia coli Antimicrobial Resistance Trends in the United States
Investigators evaluated resistance to fluoroquinolones, nitrofurantoin, and trimethoprim-sulfamethoxazole in patients with uncomplicated urinary tract infection.
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