Treatments Latest News Archive
PJI is a challenging complication of joint arthroplasty with few effective treatment options.
Children experience a median of 14 infections during their first three years of life, though there is large variation in incidence.
In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.
Investigators examined the association between infection-related medical encounters and disease-modifying treatments for multiple sclerosis.
The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.
Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.
Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.
Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.
Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.
The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.
Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.
The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.
As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.
For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.
New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.
Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.
Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone.
Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.
The FDA accepted a new drug application for plazomicin for complicated urinary tract infections.
Deintensification of treatment from chemoradiotherapy to one modality may compromise safety in patients with human papillomavirus (HPV)+ stage 1 or 2 oropharyngeal cancer.
The benefit of antibiotic treatment needs to be weighed against the potential for adverse effects, at both the individual level (adverse drug reactions) and the population level (as a driver of antibiotic resistance).
A new drug application was submitted to the FDA for oral formula to treat smallpox.
NSAIDs were found to be inferior to antibiotics for symptom relief of uncomplicated urinary tract infection.
Vabomere is now available for the treatment of adults (≥18 years old) with complicated urinary tract infections.
Secnidazole is a 5-nitroimidazole with demonstrated in vitro antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species, while sparing Lactobacillus species.
Three new guidelines discuss the best practice for Helicobacter pylori treatment.
Repeated intravenous administration of penicillin antibiotics appears to be safe in patients with a reported penicillin allergy and a negative penicillin allergy test.
Researchers believe implementation of treatment guidelines for children with sickle cell disease with acute chest syndrome may decrease hospital readmission rates.
The FDA has approved the first oral treatment for bacterial vaginosis.
Looking for a way to reduce inappropriate antibiotic use for adults with acute sore throats, researchers evaluated whether as single dose of oral corticosteriod can effectively reduce likelihood of symptom resolution.
Older age and peaked tympanogram are associated with reduced risk of treatment failure in young children with acute otitis media.
Vabomere, formerly known as Carbavance, is approved for patients with complicated UTI including pyelonephritis.
The addition of bismuth subcitrate to levofloxacin-based triple therapy is not associated with increased effectiveness in patients with Helicobacter pylori infection.
The FDA has given Fast Track designation to an oral drug candidate for treating Valley Fever.
Meningococcal disease risk has been linked to eculizumab despite previous vaccination.
Using antimicrobial dressing instead of a non-antimicrobial dressing may increase healing of diabetic foot ulcers.
The WHO issued a new list of essential medicines for 2017, adding new treatments for HIV, hepatitis C virus, and tuberculosis.
Studies sought to describe the effects of teriflunomide treatment on lymphocyte counts and infection rates in relapsing forms of multiple sclerosis (MS).
Researchers find that the spread of triazole-resistant Aspergillus fumigatus is linked to plant bulbs.
Researchers found that viruses were the most common cause of meningitis and encephalitis in the United States from 2011 to 2014.
Patients who received at least 2 doses of the recommended measles-mumps-rubella vaccine still suffered complications during an outbreak at the University of Iowa.
Bell's palsy is the only prespecified adverse event associated with the quadrivalent meningococcal conjugate vaccine.
Mortality in patients with rheumatic disease is associated with high cytomegalovirus titers.
Injections as effective as other contraceptives, but side effects prompted early halt of trial.
The FDA is mandating a Boxed Warning about the risk of HBV reactivation in certain HCV drugs.
N-Methanocarbathymidine,a novel thymidine analog antiviral being developed by N&N Pharmaceuticals Inc.,has now been granted Orphan Drug Designation by the FDA.
New balloon device approved to treat Eustachian tube dysfunction.
Vonoprazan-based triple therapy safe and effective compared with conventional PPI-based triple treatment.
If a product contains B. cepacia, its use could result in infections in patients with compromised immune systems.
Number of Medicare beneficiaries getting compounded drugs up 281% since 2006.
Report demonstrates benefit in severe photophobia secondary to trigeminal postherpetic neuralgia.
Options include acyclovir, valacyclovir, topical ganciclovir; need for development of new compounds.
WHO encourages all countries to establish blood services based on full voluntary non-remunerated blood donations.
In an updated FDA drug safety communication issued today, officials said they approved label changes for oral ketoconazole tablets in 2013 to reflect risks of serious liver damages, adrenal gland problems and drug interactions.
In a study, use of the medication was associated with a significant 61% decreased risk.
The United States spends more on prescription medications than any other country.
Study shows increased odds of cleft lip with cleft palate, d-transposition of the great arteries.
Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete.
The Salmonella Typhimurium vaccine also restored normal glucose tolerance.
Herpes simplex uveitis ID'd as cause of persistently elevated intraocular pressure after cataract surgery.
Mean cost increases with more advanced liver disease.
Broad approach recommended, which includes patient engagement and addressing barriers.
Increases seen in drugs used as direct lifesaving intervention or for high acuity conditions.
Protective effect of curcumin linked to attenuation of mitochondrial dysfunction.
The choice of prophylactic antibiotic impacts the rates of surgical site infection for women undergoing hysterectomy.
No significant difference for survival, secondary outcomes for standard, intensified treatment.
Exposure in pregnancy linked to significantly increased risk of spontaneous abortion.
Officials with the Food and Drug Administration are cautioning that dosing errors for Noxafil (posaconazole) delayed-release tablets and oral suspension have resulted due to differences in dosing regimens between the two formulations.
Cerebrospinal fluid culture results were negative following receipt of capecitabine.
Herpes zoster risk categorized after initiation of TNFi, non-TNFi, and conventional synthetic DMARDs.
Astellas announced that topline data from the a phase 3 trial, SECURE, which evaluated Cresemba (isavuconazonium sulfate) in adult patients with invasive aspergillosis.
The FDA warns of risks for ketoacidosis and serious urinary tract infections with use of SGLT2 inhibitors.
Provider members have reported challenges in obtaining prrimethamine for patients.
Brand name medications not superior to molecularly identical generic medications.
Many adults take five or more medications, often for preventable ills.
The FDA has approved U(indacaterol and glycopyrrolate (Utibron Neohaler) and glycopyrrolate (Seebri Neohaler) for the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.
Similar reduction in serum endotoxin level for low-dose, high-dose rifaximin.
Lower doses also lower unwanted side effects, researchers report.
Epilepsy drug Spritam may be one of many custom-made medicines to come that will use the technology.
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Infectious Disease Advisor Articles
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- HIV Control Criteria: Overview & Expert Roundtable
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- Antibiotic Use in Neonatal Settings in Need of Improvement
- Shorter Antibiotic Course Noninferior for Gram-Negative Bacteremia
- Rapid Antimicrobial Susceptibility Testing on Urine Directly Accelerates Results
- Antibiotics May Be Beneficial in Children With Prolonged Wet Cough
- Emergency Department Overcrowding Associated With Delayed Antibiotics in Patients With Sepsis
- Bacteria Bystanders Play Important Role in Antibiotic Resistance Development
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- Worse Outcomes in Community-Acquired Pneumonia Linked to Higher FGF21 Levels
- Bacterial Pneumonia-Complicating Influenza: Risks, Morbidity, and Mortality
- Bexsero Vaccine Has Potential for Cross-Protection Against Gonorrhea