Treatments Latest News Archive

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

PJI is a challenging complication of joint arthroplasty with few effective treatment options.

Children Typically Have 14 Simple Infections by Age 3 Years

Children Typically Have 14 Simple Infections by Age 3 Years

Children experience a median of 14 infections during their first three years of life, though there is large variation in incidence.

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.

Infection Risk With Second-Generation Disease-Modifying Treatments in MS

Infection Risk With Second-Generation Disease-Modifying Treatments in MS

Investigators examined the association between infection-related medical encounters and disease-modifying treatments for multiple sclerosis.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.

Antiherpetic Medications May Reduce Risk for Dementia

Antiherpetic Medications May Reduce Risk for Dementia

Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.

Brucellosis Treatment: Rifampicin vs Streptomycin

Brucellosis Treatment: Rifampicin vs Streptomycin

The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.

FDA Grants Priority Review for Smallpox Treatment

FDA Grants Priority Review for Smallpox Treatment

The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.

Antibiotic Prescribing Habits for UTI in Pregnant Women

Antibiotic Prescribing Habits for UTI in Pregnant Women

For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.

Lingering Symptoms of Post-Treatment Lyme Disease Explored

Lingering Symptoms of Post-Treatment Lyme Disease Explored

New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone.

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

The FDA accepted a new drug application for plazomicin for complicated urinary tract infections.

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Deintensification of treatment from chemoradiotherapy to one modality may compromise safety in patients with human papillomavirus (HPV)+ stage 1 or 2 oropharyngeal cancer.

Diclofenac Inferior to Norfloxacin for UTI, May Increase Pyelonephritis Risk

Diclofenac Inferior to Norfloxacin for UTI, May Increase Pyelonephritis Risk

The benefit of antibiotic treatment needs to be weighed against the potential for adverse effects, at both the individual level (adverse drug reactions) and the population level (as a driver of antibiotic resistance).

First Oral Smallpox Treatment Submitted to FDA for NDA

First Oral Smallpox Treatment Submitted to FDA for NDA

A new drug application was submitted to the FDA for oral formula to treat smallpox.

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

Diclofenac Inferior to Norfloxacin for UTI Symptom Relief

NSAIDs were found to be inferior to antibiotics for symptom relief of uncomplicated urinary tract infection.

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

Fixed-Dose Meropenem-Vaborbactam Available for Complicated UTI, Pyelonephritis

Vabomere is now available for the treatment of adults (≥18 years old) with complicated urinary tract infections.

Secnidazole Efficacious in Treatment of Bacterial Vaginosis

Secnidazole Efficacious in Treatment of Bacterial Vaginosis

Secnidazole is a 5-nitroimidazole with demonstrated in vitro antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species, while sparing Lactobacillus species.

New Guidelines Show Best Practices for H pylori Treatment

New Guidelines Show Best Practices for H pylori Treatment

Three new guidelines discuss the best practice for Helicobacter pylori treatment.

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

IV Penicillin Safety in Those With Allergy History But Negative Skin Test

Repeated intravenous administration of penicillin antibiotics appears to be safe in patients with a reported penicillin allergy and a negative penicillin allergy test.

Guideline-Adherent Antibiotics Decrease Readmission for Acute Chest Syndrome

Guideline-Adherent Antibiotics Decrease Readmission for Acute Chest Syndrome

Researchers believe implementation of treatment guidelines for children with sickle cell disease with acute chest syndrome may decrease hospital readmission rates.

FDA Approval: Single-Dose Oral Therapy for Bacterial Vaginosis

FDA Approval: Single-Dose Oral Therapy for Bacterial Vaginosis

The FDA has approved the first oral treatment for bacterial vaginosis.

Dexamethasone Reduces Need for Antibiotics in Adults With Sore Throat

Dexamethasone Reduces Need for Antibiotics in Adults With Sore Throat

Looking for a way to reduce inappropriate antibiotic use for adults with acute sore throats, researchers evaluated whether as single dose of oral corticosteriod can effectively reduce likelihood of symptom resolution.

Tympanogram Results May Guide Appropriate Use of Abx in Acute Otitis Media

Tympanogram Results May Guide Appropriate Use of Abx in Acute Otitis Media

Older age and peaked tympanogram are associated with reduced risk of treatment failure in young children with acute otitis media.

FDA: Vabomere Approved for Complicated UTI Following Priority Review

FDA: Vabomere Approved for Complicated UTI Following Priority Review

Vabomere, formerly known as Carbavance, is approved for patients with complicated UTI including pyelonephritis.

Efficacy of Bismuth-Based Quad Tx vs Levofloxacin Triple Tx for H pylori

Efficacy of Bismuth-Based Quad Tx vs Levofloxacin Triple Tx for H pylori

The addition of bismuth subcitrate to levofloxacin-based triple therapy is not associated with increased effectiveness in patients with Helicobacter pylori infection.

Novel Oral Antifungal Drug for Valley Fever Gets Fast Track Designation

Novel Oral Antifungal Drug for Valley Fever Gets Fast Track Designation

The FDA has given Fast Track designation to an oral drug candidate for treating Valley Fever.

Meningococcal Disease Risk Linked to Eculizumab Despite Vaccination

Meningococcal Disease Risk Linked to Eculizumab Despite Vaccination

Meningococcal disease risk has been linked to eculizumab despite previous vaccination.

Antimicrobial Dressing For Diabetic Foot Ulcers Improve Healing

Antimicrobial Dressing For Diabetic Foot Ulcers Improve Healing

Using antimicrobial dressing instead of a non-antimicrobial dressing may increase healing of diabetic foot ulcers.

New Drugs Added to the WHO 2017 Essential Medicines List

New Drugs Added to the WHO 2017 Essential Medicines List

The WHO issued a new list of essential medicines for 2017, adding new treatments for HIV, hepatitis C virus, and tuberculosis.

Low Rates of Infection, Lymphopenia With Teriflunomide Treatment for MS

Low Rates of Infection, Lymphopenia With Teriflunomide Treatment for MS

Studies sought to describe the effects of teriflunomide treatment on lymphocyte counts and infection rates in relapsing forms of multiple sclerosis (MS).

Plant Bulbs Found to Carry Triazole-Resistant Aspergillus fumigatus

Plant Bulbs Found to Carry Triazole-Resistant Aspergillus fumigatus

Researchers find that the spread of triazole-resistant Aspergillus fumigatus is linked to plant bulbs.

Viruses Most Common Cause of Meningitis, Encephalitis in the US

Viruses Most Common Cause of Meningitis, Encephalitis in the US

Researchers found that viruses were the most common cause of meningitis and encephalitis in the United States from 2011 to 2014.

Three Cases of Mumps Complications Investigated

Three Cases of Mumps Complications Investigated

Patients who received at least 2 doses of the recommended measles-mumps-rubella vaccine still suffered complications during an outbreak at the University of Iowa.

Quadrivalent Meningococcal Vaccine Linked to Bell's Palsy Risk

Quadrivalent Meningococcal Vaccine Linked to Bell's Palsy Risk

Bell's palsy is the only prespecified adverse event associated with the quadrivalent meningococcal conjugate vaccine.

CMV Titers Associated With Decrease Survival in Rheumatic Diseases

CMV Titers Associated With Decrease Survival in Rheumatic Diseases

Mortality in patients with rheumatic disease is associated with high cytomegalovirus titers.

Male Contraceptive Effective, But Adverse Events Problematic, Led to Early Study End

Male Contraceptive Effective, But Adverse Events Problematic, Led to Early Study End

Injections as effective as other contraceptives, but side effects prompted early halt of trial.

FDA: Boxed Warning Issued on Risk of HBV Using Certain HCV Drugs

FDA: Boxed Warning Issued on Risk of HBV Using Certain HCV Drugs

The FDA is mandating a Boxed Warning about the risk of HBV reactivation in certain HCV drugs.

FDA Grants N-Methanocarbathymidine Orphan Drug Designation

FDA Grants N-Methanocarbathymidine Orphan Drug Designation

N-Methanocarbathymidine,a novel thymidine analog antiviral being developed by N&N Pharmaceuticals Inc.,has now been granted Orphan Drug Designation by the FDA.

FDA Officials Approve New Balloon Device for Eustachian Tube Dysfunction

FDA Officials Approve New Balloon Device for Eustachian Tube Dysfunction

New balloon device approved to treat Eustachian tube dysfunction.

Vonoprazan-Based Triple Treatment May Be Effective Against H pylori

Vonoprazan-Based Triple Treatment May Be Effective Against H pylori

Vonoprazan-based triple therapy safe and effective compared with conventional PPI-based triple treatment.

Possible Bacterial Contamination Prompts Recall of Liquid Products

Possible Bacterial Contamination Prompts Recall of Liquid Products

If a product contains B. cepacia, its use could result in infections in patients with compromised immune systems.

Spending on Compounded Drugs Skyrocketing, Prompting Fraud Concerns

Spending on Compounded Drugs Skyrocketing, Prompting Fraud Concerns

Number of Medicare beneficiaries getting compounded drugs up 281% since 2006.

Case Study: Stellate Ganglion Block Beneficial in Postherpetic Neuralgia

Case Study: Stellate Ganglion Block Beneficial in Postherpetic Neuralgia

Report demonstrates benefit in severe photophobia secondary to trigeminal postherpetic neuralgia.

Study: New Treatment Options for Herpes Simplex Viral Keratitis Needed

Study: New Treatment Options for Herpes Simplex Viral Keratitis Needed

Options include acyclovir, valacyclovir, topical ganciclovir; need for development of new compounds.

A Call for Donations on World Blood Donor Day

A Call for Donations on World Blood Donor Day

WHO encourages all countries to establish blood services based on full voluntary non-remunerated blood donations.

FDA Issues Warning About Antifungal

FDA Issues Warning About Antifungal

In an updated FDA drug safety communication issued today, officials said they approved label changes for oral ketoconazole tablets in 2013 to reflect risks of serious liver damages, adrenal gland problems and drug interactions.

Dutasteride Reduced Risk of Prostate Biopsy-Related UTIs

Dutasteride Reduced Risk of Prostate Biopsy-Related UTIs

In a study, use of the medication was associated with a significant 61% decreased risk.

United States Could Save 73 Billion By Replacing Brand-Name Prescription Drugs

United States Could Save $73 Billion By Replacing Brand-Name Prescription Drugs

The United States spends more on prescription medications than any other country.

Fluconazole Use May Increase Risk of Certain Birth Defects

Fluconazole Use May Increase Risk of Certain Birth Defects

Study shows increased odds of cleft lip with cleft palate, d-transposition of the great arteries.

FDA Officials Warn About Potential Fluconazole, Miscarriage Link

FDA Officials Warn About Potential Fluconazole, Miscarriage Link

Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete.

Salmonella-Based Oral Vaccine Prevented Diabetes in Mice Study

Salmonella-Based Oral Vaccine Prevented Diabetes in Mice Study

The Salmonella Typhimurium vaccine also restored normal glucose tolerance.

Letter To The Editor Notes Reactivation of HSV in Patient Following Cataract Surgery

Letter To The Editor Notes Reactivation of HSV in Patient Following Cataract Surgery

Herpes simplex uveitis ID'd as cause of persistently elevated intraocular pressure after cataract surgery.

Total Medical Costs Calculated For IFN-Based Antiviral Treatment for HCV

Total Medical Costs Calculated For IFN-Based Antiviral Treatment for HCV

Mean cost increases with more advanced liver disease.

Education Key to Boosting Treatment Adherence

Education Key to Boosting Treatment Adherence

Broad approach recommended, which includes patient engagement and addressing barriers.

Drug Shortages Affecting Emergency Medicine Increased From 2008 to 2014

Drug Shortages Affecting Emergency Medicine Increased From 2008 to 2014

Increases seen in drugs used as direct lifesaving intervention or for high acuity conditions.

Curcumin Reduces Acetaminophen-Induced Hepatotoxicity in Mice

Curcumin Reduces Acetaminophen-Induced Hepatotoxicity in Mice

Protective effect of curcumin linked to attenuation of mitochondrial dysfunction.

Prophylactic Antibiotic Choice Affects Risk of Infection After Hysterectomy

Prophylactic Antibiotic Choice Affects Risk of Infection After Hysterectomy

The choice of prophylactic antibiotic impacts the rates of surgical site infection for women undergoing hysterectomy.

Intensified Treatment Doesn't Increase Survival in Tuberculous Meningitis

Intensified Treatment Doesn't Increase Survival in Tuberculous Meningitis

No significant difference for survival, secondary outcomes for standard, intensified treatment.

Oral Fluconazole Use During Pregnancy Linked to Spontaneous Abortion Risk

Oral Fluconazole Use During Pregnancy Linked to Spontaneous Abortion Risk

Exposure in pregnancy linked to significantly increased risk of spontaneous abortion.

FDA Officials Issue Warning About Dosing Errors with Antifungal

FDA Officials Issue Warning About Dosing Errors with Antifungal

Officials with the Food and Drug Administration are cautioning that dosing errors for Noxafil (posaconazole) delayed-release tablets and oral suspension have resulted due to differences in dosing regimens between the two formulations.

Fungal Meningitis Diagnosis Obscured by Antineoplastic Agent

Fungal Meningitis Diagnosis Obscured by Antineoplastic Agent

Cerebrospinal fluid culture results were negative following receipt of capecitabine.

Herpes Zoster Risk Increases in RA Patients With Older Age and Prednisone Dose

Herpes Zoster Risk Increases in RA Patients With Older Age and Prednisone Dose

Herpes zoster risk categorized after initiation of TNFi, non-TNFi, and conventional synthetic DMARDs.

Positive Data for Antifungal Treatment Published

Positive Data for Antifungal Treatment Published

Astellas announced that topline data from the a phase 3 trial, SECURE, which evaluated Cresemba (isavuconazonium sulfate) in adult patients with invasive aspergillosis.

FDA Officials Add New Warnings to SGLT2 Inhibitor Labels

FDA Officials Add New Warnings to SGLT2 Inhibitor Labels

The FDA warns of risks for ketoacidosis and serious urinary tract infections with use of SGLT2 inhibitors.

IDSA, HIVMA, PIDS, Applaud Express Scripts Efforts

IDSA, HIVMA, PIDS, Applaud Express Scripts Efforts

Provider members have reported challenges in obtaining prrimethamine for patients.

ACP: Clinicians Should Prescribe Generic Medications If Possible

ACP: Clinicians Should Prescribe Generic Medications If Possible

Brand name medications not superior to molecularly identical generic medications.

Prescription Medication Use on the Rise in the United States

Prescription Medication Use on the Rise in the United States

Many adults take five or more medications, often for preventable ills.

FDA Green Lights Two New COPD Treatments

FDA Green Lights Two New COPD Treatments

The FDA has approved U(indacaterol and glycopyrrolate (Utibron Neohaler) and glycopyrrolate (Seebri Neohaler) for the long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.

Low-Dose Rifaximin Reduces Endotoxin Level in Cirrhosis

Low-Dose Rifaximin Reduces Endotoxin Level in Cirrhosis

Similar reduction in serum endotoxin level for low-dose, high-dose rifaximin.

ASTRO: Less Chemo, Radiation May Be Effective for HPV-Related Throat Cancer

ASTRO: Less Chemo, Radiation May Be Effective for HPV-Related Throat Cancer

Lower doses also lower unwanted side effects, researchers report.

FDA Green Lights First 3D-Printed Prescription Medication

FDA Green Lights First 3D-Printed Prescription Medication

Epilepsy drug Spritam may be one of many custom-made medicines to come that will use the technology.

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