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Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.

Antiherpetic Medications May Reduce Risk for Dementia

Antiherpetic Medications May Reduce Risk for Dementia

Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.

Brucellosis Treatment: Rifampicin vs Streptomycin

Brucellosis Treatment: Rifampicin vs Streptomycin

The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.

FDA Grants Priority Review for Smallpox Treatment

FDA Grants Priority Review for Smallpox Treatment

The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.

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