Treatments

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Reason for Hope: Promising Gram-Negative Infection Treatments in the Pipeline

Reason for Hope: Promising Gram-Negative Infection Treatments in the Pipeline

Dr McKinnell provides a summary of drugs in development for infections caused by Gram-negative bacteria, including carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae.

Latest News

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.

FDA Grants Priority Review for Smallpox Treatment

FDA Grants Priority Review for Smallpox Treatment

The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.

Antibiotic Prescribing Habits for UTI in Pregnant Women

Antibiotic Prescribing Habits for UTI in Pregnant Women

For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.

Lingering Symptoms of Post-Treatment Lyme Disease Explored

Lingering Symptoms of Post-Treatment Lyme Disease Explored

New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

How Often Do Patients Select Antibiotics Over Surgery for Acute Appendicitis?

Although most patients would choose surgical intervention for treatment of acute uncomplicated appendicitis, some would opt for antibiotics alone.

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

Priority Review Granted for Treatment of Complicated UTI, Bloodstream Infections

The FDA accepted a new drug application for plazomicin for complicated urinary tract infections.

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Reducing Treatment of HPV+ Oropharyngeal Cancer May Compromise Safety

Deintensification of treatment from chemoradiotherapy to one modality may compromise safety in patients with human papillomavirus (HPV)+ stage 1 or 2 oropharyngeal cancer.

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