Treatments

FDA Approves New Treatment for Onchocerciasis

FDA Approves New Treatment for Onchocerciasis

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Moxidectin, a macrocyclic lactone, is an anthelmintic drug that selectively binds to the parasite's glutamate-gated chloride ion channels.

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

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Brincidofovir is the Company's lead candidate, a nucleotide analog that has antiviral activity against variola virus, which causes smallpox.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

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PJI is a challenging complication of joint arthroplasty with few effective treatment options.

Children Typically Have 14 Simple Infections by Age 3 Years

Children Typically Have 14 Simple Infections by Age 3 Years

Children experience a median of 14 infections during their first three years of life, though there is large variation in incidence.

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

First Single-Dose Oral Therapy for Bacterial Vaginosis Launched

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In both pivotal trials, a statistically significant greater percentage of treatment patients experienced clinical response vs those treated with placebo at 21 to 30 days following a single dose.

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

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The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.

Infection Risk With Second-Generation Disease-Modifying Treatments in MS

Infection Risk With Second-Generation Disease-Modifying Treatments in MS

Investigators examined the association between infection-related medical encounters and disease-modifying treatments for multiple sclerosis.

Risk for Breakthrough Invasive Fungal Infections With Isavuconazole: More Data Needed

Risk for Breakthrough Invasive Fungal Infections With Isavuconazole: More Data Needed

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While isavuconazole is an important therapeutic option in the management of invasive fungal infections, the epidemiology and microbiology of breakthrough infections on this agent are not well understood.

First-in-Class Antifungal Fast-Tracked for Vulvovaginal Candidiasis

First-in-Class Antifungal Fast-Tracked for Vulvovaginal Candidiasis

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SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

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The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Paracetamol Overuse During Cold and Flu Season

Paracetamol Overuse During Cold and Flu Season

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During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.

Novel Drug Combinations, Dosing Strategies Needed for <i>E faecalis</i> Bloodstream Infections

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

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Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.

Antiherpetic Medications May Reduce Risk for Dementia

Antiherpetic Medications May Reduce Risk for Dementia

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Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.

CDC Recommends Additional Malaria Treatment Option During Pregnancy

CDC Recommends Additional Malaria Treatment Option During Pregnancy

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Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

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Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

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Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.

Bezlotoxumab May Reduce Recurrent <i>C difficile</i> Infections in High-Risk Groups

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

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Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

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HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.

Brucellosis Treatment: Rifampicin vs Streptomycin

Brucellosis Treatment: Rifampicin vs Streptomycin

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The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.

Acetaminophen Use, Overdose Increases During Influenza Season

Acetaminophen Use, Overdose Increases During Influenza Season

New study finds an increase in acetaminophen use and overdosing during cold and flu season.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

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Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Treating Acute Urinary Tract Infection in Postmenopausal Women

Treating Acute Urinary Tract Infection in Postmenopausal Women

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Expert perspective on management and treatment of acute urinary tract infections in postmenopausal women.

Flucytosine plus fluconazole is noninferior to amphotericin B in treating cryptococcal meningitis

Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

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Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

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Use of oseltamivir does not appear to increase the risk of suicide in pediatric patients.

Treatment for MRSA Complicated Bacteremia and Infective Endocarditis

Treatment for MRSA Complicated Bacteremia and Infective Endocarditis

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Further studies are warranted to assess the efficacy and safety of fosfomycin plus imipenem against methicillin-resistant Staphylococcus aureus complicated infections.

Sepsis Recovery Requires an All-Hands Approach

Sepsis Recovery Requires an All-Hands Approach

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After hospital discharge for sepsis, the healthcare team should focus on identifying new functional, mental, and cognitive impairments and referring patients to appropriate treatment; reviewing and adjusting long-term medications; and evaluating for treatable conditions that commonly result in hospitalizations.

<i>Eggerthella lenta</i> Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

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Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.

Meropenem-vaborbactam noninferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial

In this randomized controlled trial, meropenem-vaborbactam was found to be noninferior to piperacillin-tazobactam for treating complicated urinary tract infections.

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

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Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.

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