During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.
Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.
Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.
Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.
Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.
Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.
Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.
HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.
The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.
New study finds an increase in acetaminophen use and overdosing during cold and flu season.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Expert perspective on management and treatment of acute urinary tract infections in postmenopausal women.
Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.
Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.
Use of oseltamivir does not appear to increase the risk of suicide in pediatric patients.
Further studies are warranted to assess the efficacy and safety of fosfomycin plus imipenem against methicillin-resistant Staphylococcus aureus complicated infections.
After hospital discharge for sepsis, the healthcare team should focus on identifying new functional, mental, and cognitive impairments and referring patients to appropriate treatment; reviewing and adjusting long-term medications; and evaluating for treatable conditions that commonly result in hospitalizations.
Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.
Meropenem-vaborbactam noninferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trialMarch 02, 2018
In this randomized controlled trial, meropenem-vaborbactam was found to be noninferior to piperacillin-tazobactam for treating complicated urinary tract infections.
Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.
The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.
As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.
In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 associated myelopathy was safe and associated with improvement in biomarkers of disease, as well as improvements in spasticity and motor disability.
For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.
New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.
Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.
Researchers conducted a systematic review and meta-analysis to assess the effectiveness and safety of short-term vs prolonged infusion of antipseudomonal β-lactams in patients with sepsis.
The hepatitis C treatment, sofosbuvir was found to be effective against Zika virus in a preclinical trial.
Vancomycin is the first liquid oral treatment for C diff-associated diarrhea.
Recent significantly increased influenza activity prompts CDC advisory for antiviral treatment.
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Infectious Disease Advisor Articles
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- Pregnancy May Be Independently Associated With Prolonged Detection of Zika Virus RNA
- Clostridium difficile Infection in the Intensive Care Setting
- Combating Medically Important Antibiotic Use in Food-Producing Animals
- Religious Exemptions vs Mandatory Vaccinations: An Expert Perspective
- 2018 Vaccination Schedule: Adults
- Fingerstick Point-of-Care Test Allows for Single-Visit HCV Diagnoses
- Glecaprevir/Pibrentasvir Highly Efficacious for HCV/HIV Coinfection
- Fluoroquinolone Use May Increase Risk for Aortic Aneurysm and Dissection
- Reduced Risk of Hepatocellular Carcinoma in DAA-Treated HCV Infection
- Paracetamol Overuse During Cold and Flu Season
- C difficile Risk Higher With Stoma Reversal vs Colectomy