There is currently a global outbreak of disseminated Mycobacterium chimaera related to the widely used surgical device LivaNova 3T heater-cooler unit contamination.
The ERADICATE Hp2 trial enrolled 455 dyspepsia patients at 55 sites across the US and randomized them to receive 4 capsules, 3 times daily, of either Talicia or the active comparator, for 14 days.
Treatment for cutaneous leishmaniasis caused by Leishmania braziliensis, using 15% paromomycin-Aquaphilic, was superior to a negative vehicle control.
Investigators evaluated the safety and effectiveness of conventional therapy with biologic immunosuppressive drugs to treat patients with HIV infection and psoriasis.
For patients with serious infectious diseases, the first 48 hours represent a critical window for antibiotic administration.
Screening recommended for those ages 15 to 65 years, including pregnant women.
In order to determine HCV reinfection rates following sustained virologic response (SVR) in the overall population as well as in PWID, the study authors analyzed data obtained from a population-based study that included >1.7 million people that were tested for HCV.
Six-week antibiotic treatment is sufficient for early, spinal surgery site infections.
Glecaprevir/Pibrentasvir 8-Week Regimen Evaluated in Treatment-Naïve HCV Patients With Compensated CirrhosisNovember 19, 2018
In EXPEDITION-8, 280 treatment-naïve HCV patients (genotypes 1, 2, 4, 5, and 6) with compensated cirrhosis were treated with Mavyret for 8-weeks; the primary efficacy measure was SVR12 rate.
The study compared US administrative claims data of HCV patients with ≥12 weeks of dispensed DAA therapy (N=17,848) to untreated HCV patients with follow-up data (N=108,350).
Poor clinical outcomes linked to extended spectrum cephalosporin-resistant Enterobacteriaceae.
The aim of the study was to assess both treatment evaluation and treatment initiation rates from various practice settings between January 2002 and December 2016.
Anidulafungin, caspofungin, and micafungin have shown similar risk profiles for severe hepatotoxicity.
Shedding of Salmonella Typhi or Paratyphi in the stool/urine leads to contamination of food/water, but vaccines can reduce stool shedding.
A dispersible fixed-dose combination tablet formulation of abacavir/dolutegravir/lamivudine for the treatment of HIV-1 had higher bioavailability of dolutegravir compared to the nondispersible film-coated tablet.
From 2014 to 2016 there was an increase in the annual number of HIV preexposure prophylaxis (PrEP) users in the United States.
Patients admitted from the community who are hospitalized with Clostridioides (formerly Clostridium) difficile infection were more frequently discharged to a non-home location compared to patients without C difficile infection.
A seven-day dose of metronidazole is associated with a reduced likelihood of being Trichomonas vaginalis-positive at test-of-cure compared with single-dose treatment.
A ratio of free drug area under the concentration-time curve to MIC for daptomycin was linked with an higher 30-day survival in some with bacteremia.
Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.
When compared to placebo, baloxavir marboxil was associated with reduced risk of influenza complications and faster recovery.
Treatment for hepatitis C is associated with a reduction in cardiovascular events.
The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.
Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.
A natural variability of genotype-determined, CYP2D6-dependent metabolism of primaquine phosphate is associated with an increased risk of failure in the treatment of P vivax malaria.
The Phase 3 ReSPECT prophylaxis trial of rezafungin in patients undergoing allogeneic bone marrow transplantation is anticipated to start in the first quarter of 2019.
Chloroquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border.
Tenofovir diphosphate in dried blood spots was strongly associated with virologic suppression in those living with HIV on TDF-based therapies.
The use of corticosteroids in sepsis appears to modestly reduce the risk for death and modestly increase neuromuscular weakness but the evidence is not definitive.
Higher minimum inhibitory concentration values of isoniazid or rifampin are associated with a greater risk of relapse in drug-susceptible tuberculosis than lower MICs.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Topical Antibacterial Agent Effective for Treatment of Impetigo
- Novel H pylori Eradication Therapy Effective in Phase 3 Trial
- Polymyxin B Hemoperfusion Does Not Change Mortality Rate in Septic Shock
- Addiction Medicine Consultation Improves Antibiotic Compliance in Patients with Opioid Use Disorders
- Guideline Adoption for Childhood Community-Acquired Pneumonia