Treatments

Paracetamol Overuse During Cold and Flu Season

Paracetamol Overuse During Cold and Flu Season

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During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.

Novel Drug Combinations, Dosing Strategies Needed for <i>E faecalis</i> Bloodstream Infections

Novel Drug Combinations, Dosing Strategies Needed for E faecalis Bloodstream Infections

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Review highlights available treatment options and their limitations and provides direction for investigation of future novel combination therapies to further aid in the treatment of Enterococcus faecalis infective endocarditis.

Antiherpetic Medications May Reduce Risk for Dementia

Antiherpetic Medications May Reduce Risk for Dementia

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Patients with herpes simplex virus infections may have a 2.56-fold increased risk for developing dementia, and using antiherpetic medications may decrease dementia risk.

CDC Recommends Additional Malaria Treatment Option During Pregnancy

CDC Recommends Additional Malaria Treatment Option During Pregnancy

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Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

Colistin Plus Meropenem Not Superior to Monotherapy for Carbapenem-Resistant Gram-Negative Bacteria

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Results strongly support the avoidance of colistin-carbapenem combination therapy for carbapenem-resistant A baumannii infections regardless of the infection source.

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

Adverse Outcome Risks With Trimethoprim After UTI in Older Adults

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Results showed that trimethoprim was associated with greater risk for acute kidney injury and hyperkalemia compared with other antibiotic drugs for UTI in older adults.

Bezlotoxumab May Reduce Recurrent <i>C difficile</i> Infections in High-Risk Groups

Bezlotoxumab May Reduce Recurrent C difficile Infections in High-Risk Groups

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Subgroup analyses of 2 MODIFY trial data confirmed prior C difficile infection (CDI), age ≥65 years, infection with 027/078/244 strain, compromised immunity, and severe CDI are risk factors for recurrent CDI.

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

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HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.

Brucellosis Treatment: Rifampicin vs Streptomycin

Brucellosis Treatment: Rifampicin vs Streptomycin

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The findings of this study indicated that rifampicin therapy significantly increased the risk of overall failure and relapse compared with streptomycin.

Acetaminophen Use, Overdose Increases During Influenza Season

Acetaminophen Use, Overdose Increases During Influenza Season

New study finds an increase in acetaminophen use and overdosing during cold and flu season.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

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Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Treating Acute Urinary Tract Infection in Postmenopausal Women

Treating Acute Urinary Tract Infection in Postmenopausal Women

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Expert perspective on management and treatment of acute urinary tract infections in postmenopausal women.

Flucytosine plus fluconazole is noninferior to amphotericin B in treating cryptococcal meningitis

Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

Standard-Dose vs Low-Dose Azithromycin for Treatment of Yaws

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Low-dose azithromycin did not meet the prespecified noninferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws.

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

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Use of oseltamivir does not appear to increase the risk of suicide in pediatric patients.

Treatment for MRSA Complicated Bacteremia and Infective Endocarditis

Treatment for MRSA Complicated Bacteremia and Infective Endocarditis

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Further studies are warranted to assess the efficacy and safety of fosfomycin plus imipenem against methicillin-resistant Staphylococcus aureus complicated infections.

Sepsis Recovery Requires an All-Hands Approach

Sepsis Recovery Requires an All-Hands Approach

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After hospital discharge for sepsis, the healthcare team should focus on identifying new functional, mental, and cognitive impairments and referring patients to appropriate treatment; reviewing and adjusting long-term medications; and evaluating for treatable conditions that commonly result in hospitalizations.

<i>Eggerthella lenta</i> Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

Eggerthella lenta Bloodstream Infections: Increased Mortality Risk With Piperacillin-Tazobactam

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Eggerthella lenta displays high minimal inhibitory concentrations to piperacillin-tazobactam (TZP), and empiric TZP monotherapy is a risk factor for 30-day mortality.

Meropenem-vaborbactam noninferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial

In this randomized controlled trial, meropenem-vaborbactam was found to be noninferior to piperacillin-tazobactam for treating complicated urinary tract infections.

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

Current Ivermectin Schedule Does Not Cure Strongyloidiasis

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Further studies are required to evaluate the effectiveness of the ivermectin schedule for treatment of strongyloidiasis, and quantitative methods of high sensitivity and accuracy are needed to monitor treatment success or to predict reactivation.

FDA Grants Priority Review for Smallpox Treatment

FDA Grants Priority Review for Smallpox Treatment

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The FDA has accepted and granted priority review for TPOXX, an antiviral therapy for smallpox.

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

Oral Fexinidazole Safe, Effective for Late-Stage Trypanosomiasis

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As first-line treatment for human African trypanosomiasis requires administration in a hospital by trained personal, a short-course oral option presents significant advantages for managing patients with this tropical disease.

Mogamulizumab is safe and possibly effective in HTLV-1-associated myelopathy

In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 associated myelopathy was safe and associated with improvement in biomarkers of disease, as well as improvements in spasticity and motor disability.

Antibiotic Prescribing Habits for UTI in Pregnant Women

Antibiotic Prescribing Habits for UTI in Pregnant Women

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For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.

Lingering Symptoms of Post-Treatment Lyme Disease Explored

Lingering Symptoms of Post-Treatment Lyme Disease Explored

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New research may explain why many patients report lingering symptoms after receiving antibiotic therapy for the treatment of Lyme disease.

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

Antibiotics Frequently Prescribed for Suspected UTI in Nursing Home Residents

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Five factors were found to be significantly associated with UTI antibiotic use in order of decreasing association: presence of urinary catheter, urinary frequency, fever, new-onset hypotension, and confusion.

Assessment of Prolonged vs Short-Term Antipseudomonal β-lactam Infusion for Sepsis

Assessment of Prolonged vs Short-Term Antipseudomonal β-lactam Infusion for Sepsis

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Researchers conducted a systematic review and meta-analysis to assess the effectiveness and safety of short-term vs prolonged infusion of antipseudomonal β-lactams in patients with sepsis.

Hepatitis C Drug Effective Against Zika Virus in Preclinical Trial

Hepatitis C Drug Effective Against Zika Virus in Preclinical Trial

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The hepatitis C treatment, sofosbuvir was found to be effective against Zika virus in a preclinical trial.

FDA: Vancomycin Liquid Oral Treatment Approved for <i>C diff</i>-Associated Diarrhea

FDA: Vancomycin Liquid Oral Treatment Approved for C diff-Associated Diarrhea

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Vancomycin is the first liquid oral treatment for C diff-associated diarrhea.

CDC Seasonal Influenza A(H3N2) Activity and Treatment Advisory

CDC Seasonal Influenza A(H3N2) Activity and Treatment Advisory

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Recent significantly increased influenza activity prompts CDC advisory for antiviral treatment.

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