Hepatitis B Virus Treatments
|HEPATITIS B VIRUS TREATMENTS|
|adefovir dipivoxil||Hepsera||Adults: 10mg once daily. Renal impairment: CrCl 30−49mL/min: 10mg every 48hrs; CrCl 10−29mL/min: 10mg every 72hrs; CrCl<10mL/min (on hemodialysis): 10mg every 7 days after dialysis; (not on hemodialysis): not recommended.
Children: Not recommended.
|entecavir||Baraclude*||Adults: ≥16yrs: Take on empty stomach. Compensated
liver disease: (nucleoside-naïve): 0.5mg once daily; (lamivudine-refractory or known
lamivudine or telbivudine resistance mutations): 1mg once daily. Decompensated liver
disease: 1mg once daily. Renal impairment (nucleoside-naive): CrCl 30−49mL/min: 0.25mg once daily or 0.5mg every 48hrs; CrCl 10−29mL/min: 0.15mg once daily or 0.5mg every 72hrs; CrCl<10mL/min or on hemodialysis: 0.05mg once daily or 0.5mg every 7 days; (lamivudine-refractory or decompensated liver disease): CrCl 30−49mL/min: 0.5mg once daily or 1mg every 48hrs; CrCl 10−29mL/min: 0.3mg once daily or 1mg every 72hrs; CrCl<10mL/min or on hemodialysis: 0.1mg once daily or 1mg every 7 days. If on hemodialysis day, give after session.
Children: <2yrs: Not established.Take on empty stomach. Give once daily. ≤30kg: use oral soln. ≥2yrs (nucleoside-naive): 10–11kg: 3mL; 12–14kg: 4mL; 15–17kg: 5mL; 18–20kg: 6mL; 21–23kg: 7mL; 24–26kg: 8mL; 27–30kg: 9mL; >30kg: 10mL or 0.5mg tab; (lamivudine-experienced): 10–11kg: 6mL; 12–14kg: 8mL; 15–17kg: 10mL; 18–20kg: 12mL; 21–23kg: 14mL; 24–26kg: 16mL; 27–30kg: 18mL; >30kg: 20mL or 1mg tab.
|Baraclude Oral Solution*|
|interferon alfa‑2b||Intron A||Adults: ≥18yrs: 5 million IU daily or 10million IU IM or SC three times weekly for 16wks.
Children: <1yr: Not established. 1–17yrs: 3million IU/m2 SC three times weekly for 1wk, then increase to 6million IU/m2 (max 10 million IU) three times weekly for a total of 16–24wks.
|lamivudine||Epivir‑HBV||Adults: 100mg once daily. Renal impairment: CrCl 30−49mL/min: 100mg for 1st dose then 50mg once daily; CrCl 15−29mL/min: 100mg for 1st dose then 25mg once daily; CrCl 5−14mL/min: 35mg for 1st dose then 15mg once daily; CrCl<5mL/min: 35mg for 1st dose then 10mg once daily.
Children: <2yrs: Not established. 2−17yrs: 3mg/kg (max 100mg) once daily.
|peginterferon alfa‑2a||Pegasys||Adults: 180mcg once weekly for 48wks. CrCl<30mL/min or ESRD on hemodialysis: 135mcg SC once weekly; may reduce to 90mcg once weekly if severe reactions develop; if intolerance persists, discontinue.
Children: <3yrs: Not established. ≥3yrs: 180mcg/1.73m2 x BSA SC once weekly for 48wks; max dose 180mcg. Maintain pediatric dose through duration of therapy in those who turn 18yrs.
|tenofovir alafenamide||Vemlidy||Adults: ≥18yrs: Take with food. 25mg once daily. Concomitant carbamazepine: 50mg once daily. Hemodialysis: give after session.
Children: <18yrs: Not established.
|tenofovir disoproxil fumarate||Viread||Adults: ≥35kg: 300mg once daily. Renal impairment: CrCl 30–49mL/min: 300mg every 48hrs; CrCl 10–29mL/min: 300mg every 72–96hrs; hemodialysis: 300mg every 7 days or after a total of 12hrs of dialysis; CrCl <10mL/min: not recommended.
Children: <2yrs (<10kg): Not established. Mix oral pwd with 2–4oz of soft food not requiring chewing (eg, applesauce, baby food, yogurt). Oral pwd (≥2yrs [≥10kg] or Tabs ≥2yrs [≥17kg]): 8mg/kg once daily; max 300mg/day. Tabs (if able to swallow): ≥2yrs (17–<22kg): 150mg once daily; (22–<28kg): 200mg once daily; (28–<35kg): 250mg once daily; (≥35kg): 300mg once daily.
|Viread Oral Powder|
*For doses <0.5mg, use oral solution.
This article originally appeared on MPR