Urinary Tract Infections

Latest News

Inappropriate Antibiotic Prescribing for Uncomplicated Cystitis Still Occurs

By

Natasha Persaud

Urologists appear more likely than other specialists to inappropriately treat uncomplicated cystitis, according to study findings.

Rosuvastatin Increases Risk for Hematuria, Proteinuria

By

Natasha Persaud

Few real-world studies have investigated the risks of hematuria and proteinuria associated with rosuvastatin use.

Endometrial Cancer Ups Risks for UTI, Kidney Failure

By

Jody A. Charnow

The increased risk for several urinary tract problems among women diagnosed with endometrial cancer varies by age and race or ethnicity, a study found.

FDA Needs More Data on Tebipenem HBr for Complicated UTI

By

Brian Park, PharmD

In the CRL, the FDA stated that the application could not be approved in its present form and that an additional clinical trial would be required.

Travelers’ Diarrhea Significantly Increases Urinary Tract Infection Risk

By

Colby Stong

Researchers assessed whether there is an association between urinary tract infection incidence and international travel.

Gut Dysbiosis Identified in Women With Recurrent UTI

Women with rUTIs have a gut microbiome that is significantly depleted in microbial richness and butyrate-producing bacteria.

Patient Race May Be a Proxy for Other Factors in Predictive Models for UTI Risk in Children

By

Estie Mermelstein, MSN, FNP-BC

In this meta-analysis, researchers assessed whether patient race is a proxy for other factors in predictive models that show an association between race and urinary tract infection risk.

Zerbaxa Approved for Complicated Pediatric Intra-abdominal, Urinary Tract Infections

By

Brian Park, PharmD

The approvals were based on data from pediatric trials evaluating treatment for complicated intra-abdominal infections and complicated urinary tract infections.

Role of Race in Calculating UTI Risk in Children Reassessed

The variable race is associated with UTI in children, but it can be replaced with history of UTI and duration of fever in a previously developed prediction tool.

FDA: Sotrovimab No Longer Authorized to Treat COVID-19 in Any US Region

By

Brian Park, PharmD

As of April 5, 2022, CDC Nowcast data reported that the BA.2 subvariant accounted for more than 50% of cases in all US states and territories.

Oral Tebipenem Effectively Treats Complicated UTI, Pyelonephritis

By

Natasha Persaud

Tebipenem pivoxil hydrobromide is an orally bioavailable carbapenem with activity against uropathogenic Enterobacterales.

Cefepime-Taniborbactam Bests Meropenem in Complicated UTI Trial

By

Brian Park, PharmD

The phase 3 CERTAIN-1 study compared the efficacy and safety of cefepime-taniborbactam to meropenem in 661 adults with cUTI.

MV140 Vaccine May Prevent Recurrent Urinary Tract Infections

By

Natasha Persaud

MV140 is a sublingual vaccine of whole-cell inactivated bacteria that may be an alternative to frequent antibiotics for recurrent urinary tract infections.

Antibiotic Stewardship Increases Use of Guideline-Concordant Antibiotics for UTI

By

Jessica Nye, PhD

Researchers conducted a study to assess the effect of an antibiotic stewardship program on the use of appropriate antibiotic therapy among patients with urinary tract infections in the ED.

Tebipenem HBr Gets Priority Review for Oral Treatment of Complicated UTI

By

Brian Park, PharmD

The application includes data from the phase 3 ADAPT-PO trial, which evaluated the efficacy and safety of tebipenem HBr in 868 adults with cUTI or acute pyelonephritis.

Safety, Efficacy of Aminoglycosides or Polymyxin Monotherapy for Complicated UTI

By

Bradley van Paridon

Researchers conducted a study to assess the safety and efficacy of aminoglycosides or polymyxin monotherapy for the treatment of adults with complicated urinary tract infections caused by extensively drug-resistant Pseudomonas aeruginosa.

Educating Nursing Care Facility Staff Decreases Inappropriate Antibiotic Treatment for Urinary Tract Infection

By

Bradley van Paridon

Researchers sought to determine whether an intervention to improve the knowledge and communication skills of nursing care facility staff decreases the number of inappropriate antibiotic prescriptions for patients with suspected urinary tract infection.

Probability of Progression to Complicated Urinary Tract Infection in Women With Antimicrobial-Resistant Isolates

By

Infectious Disease Advisor Contributing Writer

Study finds that among women with uncomplicated urinary tract infection (UTI), those with antimicrobial-resistant isolates are at increased risk for progression to complicated UTI vs those with susceptible isolates.

Effect of Probenecid on Cephalexin Pharmacokinetics and Pharmacodynamics

By

Bradley van Paridon

Researchers conducted a crossover study to determine whether probenecid and cephalexin administered together increases the clinical benefits of cephalexin.

Community-Acquired Urinary Tract Infection: Adverse Effects of Cotrimoxazole vs Fluoroquinolones

By

Rita Aghjayan

Investigators conducted a cohort study that compared adverse effects and outcomes among patients with community-acquired urinary tract infection treated with cotrimoxazole vs fluoroquinolones.