Urinary Tract Infections

Latest News

Effect of Probenecid on Cephalexin Pharmacokinetics and Pharmacodynamics

By

Bradley van Paridon

Researchers conducted a crossover study to determine whether probenecid and cephalexin administered together increases the clinical benefits of cephalexin.

Community-Acquired Urinary Tract Infection: Adverse Effects of Cotrimoxazole vs Fluoroquinolones

By

Rita Aghjayan

Investigators conducted a cohort study that compared adverse effects and outcomes among patients with community-acquired urinary tract infection treated with cotrimoxazole vs fluoroquinolones.

Frailty Ups Risk for Urinary Tract Infections in Patients With Diabetes, CKD

By

Natasha Persaud

More severe frailty predicted a higher risk of UTIs.

Study Supports Shorter Antibiotic Course for Afebrile Men With UTI

By

Cassandra Pardini, PharmD

The double-blinded, placebo-controlled noninferiority study included a total of 272 afebrile men from 2 US Veterans Affairs medical centers.

FDA Needs More Data on Sulopenem for Uncomplicated UTI

By

Diana Ernst, RPh

The NDA submission was supported by data from the phase 3 SURE1 clinical trial.

UTI Study Maps Escherichia coli Antimicrobial Resistance Trends in the United States

By

Estie Mermelstein, MSN, FNP-BC

Investigators evaluated resistance to fluoroquinolones, nitrofurantoin, and trimethoprim-sulfamethoxazole in patients with uncomplicated urinary tract infection.

High Glycosuria Environment Allows for Increased Growth, Adherence of Group B Streptococcus

By

Jessica Nye, PhD

Investigators conducted a study to assess the effects of moderate glycosuria on groupB Streptococcus .

Urinary Tract Infection Prophylaxis Among Older Adults Increase Risks

By

Joyce Lee, PharmD, RPh

Study authors examined 186,589 patients with an initial positive urine culture and receiving antibiotics to quantify risks and benefits of UTI prophylaxis in older adults.

Urinary Tract Infection in Multiple Sclerosis: Risk, Diagnosis, and Management

By

Amit Akirov, MD

Amit Akirov, MD, discusses the risk, prevalence, diagnosis, and management of urinary tract infections among patients with multiple sclerosis.

Infectious Diseases Consultation Effectively Reduces Antibiotic Use in Hospitals

By

Sweta Gupta

Investigators assessed whether a daily service of infectious disease consultation was more effective than weekly consultation to reduce antibiotic use without worsening clinical outcomes.

Oral Beta-Lactams Effective Step-Down Therapy for Bacteremic UTI

By

Zahra Masoud

Study authors compared clinical cure in patients with E coli bacteremic UTI who were stepped down to oral beta-lactams compared to oral fluoroquinolones.

CREDIBLE-CR: Cefiderocol Effective for Serious Carbapenem-Resistant Gram-Negative Infections

By

Bradley van Paridon

Study authors assessed the efficacy and safety of cefiderocol vs best available therapy in adults with serious carbapenem-resistant Gram-negative infections.

Tool Could Optimize Antibiotic Prescribing for UTI

Researchers tested a new decision support tool to optimize antibiotic prescribing for uncomplicated urinary tract infection.

Intravesical Phage Therapy May Treat UTI in Men Undergoing TURP

By

Sweta Gupta

Research authors assessed the safety and efficacy of intravesical bacteriophage therapy compared to placebo and current standard of care for the treatment of urinary tract infection in patients undergoing transurethral resection of the prostate.

Protocolized Urine Sampling Reduces Catheter-Associated UTI

By

Zahra Masoud

Investigators sought to determine whether a new protocol for urine sampling and testing lowers rates of catheter-associated urinary tract infections.

Menopausal Hormonal Therapy May Cut UTI Risk

By

Natasha Persaud

New study is the first focused analysis of bacterial diversity in the urogenital tract of postmenopausal women, according to investigators.

Infection May Increase Risk for Early Stroke Recurrence

By

Amit Akirov, MD

Infection may be associated with an increased risk for early stroke recurrence in hospitalized patients with acute ischemic stroke.

Shorter Antibiotic Treatment Duration Effective for Acute Uncomplicated Cystitis

By

Zahra Masoud

A team of investigators conducted a systematic review and meta-analysis to assess whether a shorter-than-recommended duration of antibiotic treatment can be effective for the management of acute uncomplicated cystitis.

Multiple-Dose Fosfomycin for Complicated UTIs

By

Bradley van Paridon

In cases of complicated urinary tract infections (UTI) treated with multiple-dose fosfomycin, clinical resolution occurred in 2 of 3 treatment episodes.

Novel Cephalosporin Now Available for Treatment of Complicated UTI

By

Diana Ernst, RPh

Fetroja® (cefiderocol) has been made available by Shionogi for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex.