Vector-Borne Illness

Screening Blood Donations Mitigates Transfusion-Transmitted Babesiosis Risk

Screening Blood Donations Mitigates Transfusion-Transmitted Babesiosis Risk

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Screening blood donations for Babesia microti in endemic areas eliminates transfusion-transmitted babesiosis effectively.

Safety of Escalating Doses of Tribendimidine in Children With Hookworm

Safety of Escalating Doses of Tribendimidine in Children With Hookworm

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Tribendimidine 400 mg has demonstrated efficacy and tolerability in children with mild hookworm infections.

Certain Iron Deficiencies May Protect Against Malaria in African Children

Certain Iron Deficiencies May Protect Against Malaria in African Children

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Iron deficiency may protect African children against malaria infection when defined using ferritin and transferrin saturation.

CDC: First Case of Rat-Borne Andes Virus Diagnosed in the US

CDC: First Case of Rat-Borne Andes Virus Diagnosed in the US

The first confirmed U.S. case of a virus carried by South American rodents occurred earlier this year.

Flea-Borne Typhus Outbreak in Los Angeles County

Flea-Borne Typhus Outbreak in Los Angeles County

An outbreak of flea-borne typhus in Los Angeles County has so far resulted in 57 cases, including 20 in Pasadena and nine in downtown Los Angeles.

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

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A natural variability of genotype-determined, CYP2D6-dependent metabolism of primaquine phosphate is associated with an increased risk of failure in the treatment of P vivax malaria.

Short Course Primaquine Regimens for <i>P vivax</i> Malaria Improves Treatment Efficacy

Short Course Primaquine Regimens for P vivax Malaria Improves Treatment Efficacy

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Chloroquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border.

New Q Fever Foci Identified, Including Acute Endocarditis, Lymphadenitis

New Q Fever Foci Identified, Including Acute Endocarditis, Lymphadenitis

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Acute endocarditis, lymphadenitis, and bone marrow involvement in hemophagocytic syndrome have been newly identified as Q fever foci.

Threat of Zika Virus Still Significant in California

Threat of Zika Virus Still Significant in California

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Since 2015, California has seen many travel-related Zika virus cases, and as the population of mosquitos that spread the virus continue to expand across the state, there is a significant risk for new Zika cases.

Permethrin Plus Pyriproxyfen-Treated Bednets Reduce Malaria Transmission

Permethrin Plus Pyriproxyfen-Treated Bednets Reduce Malaria Transmission

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Long-lasting insecticidal nets treated with permethrin plus pyriproxyfen are more effective in preventing clinical malaria compared with standard insecticidal nets.

Dengue Vaccine Presents Solutions and Backlash in Dengue-Endemic Regions

Dengue Vaccine Presents Solutions and Backlash in Dengue-Endemic Regions

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The principles of "trolleyology" can be used to understand hesitancy among certain individuals to vaccinate against the Dengue virus.

Suboptimal Diagnostics Affect Management of Tickborne Diseases

Suboptimal Diagnostics Affect Management of Tickborne Diseases

Diagnostic and surveillance limitations and lack of treatment options, vaccines hamper efforts.

Sustained Follow-Up Essential for Infants of Women Exposed to Zika Virus

Sustained Follow-Up Essential for Infants of Women Exposed to Zika Virus

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Approximately 14% of children who were born to mothers with confirmed or possible Zika virus infection during pregnancy were identified during infancy or early childhood as having a Zika-associated birth defect.

CDC Advises That Benznidazole Now Only Available Through Drug Company

CDC Advises That Benznidazole Now Only Available Through Drug Company

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CDC announced that, effective May 14 2018, the CDC Investigational New Drug (IND) treatment protocols will no longer be providing benznidazole for the treatment of Chagas disease.

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

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Health professionals from many disciplines need to be able to recognize the clinical presentations, essential diagnostic tests, and treatment approach of Lyme neuroborreliosis.

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

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In clinical trials, tafenoquine, an 8-aminoquinoline, demonstrated efficacy against 2 primary types of malaria, Plasmodium vivax and P. falciparum malaria.

Lyme-Bearing Ticks More Widespread in US Than Thought

Lyme-Bearing Ticks More Widespread in US Than Thought

Ticks capable of transmitting Lyme disease and other tick-borne illnesses have been identified in dozens of places across the United States where the pests had never previously been recorded.

Single-Dose Krintafel Approved for the Radical Cure of <i>P vivax</i> Malaria

Single-Dose Krintafel Approved for the Radical Cure of P vivax Malaria

The FDA approved Krintafel for the radical cure of Plasmodium vivax malaria in patients ≥16 years old who are receiving appropriate antimalarial therapy for acute P vivax infection.

Tick-Caused Meat Allergy on the Rise in the United States

Tick-Caused Meat Allergy on the Rise in the United States

Red meat allergy caused by a bite from the lone star tick appears to be on the rise in the United States.

Vivax Malaria Relapses Predominantly Delayed by Chloroquine, Prevented by Primaquine

Vivax Malaria Relapses Predominantly Delayed by Chloroquine, Prevented by Primaquine

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The benefits of using slowly eliminated chloroquine vs rapidly eliminated arsenuate anti-malarials were assessed in a 3-way randomized comparison trial.

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

Lyme Neuroborreliosis: Long-Term Survival and Health Outcomes

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Lyme neuroborreliosis diagnosis had no substantial effect on long-term survival, health, or educational/social functioning yet may be associated with an increased risk of hematologic and nonmelanoma skin cancers.

Using Digital Technology to Detect Vector-Borne Diseases

Using Digital Technology to Detect Vector-Borne Diseases

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Although internet-based surveillance methods have recently been established to enhance vector-borne disease surveillance, assessment of their utility is required to determine how best to position this technology to improve infectious disease outcomes.

Predictors of Post-Chikungunya Chronic Polyarthralgia

Predictors of Post-Chikungunya Chronic Polyarthralgia

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Researchers reported on the first outbreak of an Asian lineage of chikungunya virus in Aruba.

Synovial Fluid Cell Counts Do Not Accurately Differentiate Arthritis Types

Synovial Fluid Cell Counts Do Not Accurately Differentiate Arthritis Types

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Accurate and rapid diagnostics methods are needed to inform initial clinical decision making for patients with hip monoarthritis.

Long-Lasting Insecticidal Nets Improved Malaria Control Over Standard Methods

Long-Lasting Insecticidal Nets Improved Malaria Control Over Standard Methods

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As a direct consequence of this trial, WHO revised its policy on long-lasting insecticidal nets in September, 2017, gave interim endorsement to pyrethroid-piperonyl butoxide nets as a new WHO class of vector control product.

Despite Pyrethroid Resistance, Insecticidal Nets Protect Against Malaria

Despite Pyrethroid Resistance, Insecticidal Nets Protect Against Malaria

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In some locations, malaria incidence remained high despite high use of nets, emphasizing the need for new tools and approaches for malaria prevention if targets for the reduction of the global malaria burden are to be achieved.

Vaccine for Chikungunya Prevention Gets Fast Track Designation

Vaccine for Chikungunya Prevention Gets Fast Track Designation

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The Phase 2b study is in the process of enrolling 400 people to evaluate multiple dosing regimens. PaxVax expects the results in early 2019.

Vector-Borne Diseases Up More Than 2-Fold From 2004 to 2016

Vector-Borne Diseases Up More Than 2-Fold From 2004 to 2016

Vector-borne diseases represent an increasing problem in the United States, with a more than 2-fold increase in the number of annual reports from 2004 to 2016.

CDC Recommends Additional Malaria Treatment Option During Pregnancy

CDC Recommends Additional Malaria Treatment Option During Pregnancy

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Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.

Malaria Therapy During Pregnancy Needs a Translational Booster

Malaria Therapy During Pregnancy Needs a Translational Booster

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First trimester treatment for malaria could change with the results of 1 of the most robust meta-analyses to date that compared artemisinin-based therapy vs quinine.

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